Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

Rauscher Virus性マウス白血病における溶血性貧血に関する研究 第2編 網内系機能の変動について

水川 市郎 岡山大学医学部第二内科教室
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Using Rauscher leukemia virus, changes in the reticuloendothelial phagocytic activity were studied by a carbon clearance method and a heat-damaged (51)Cr-labelled red blood cell method. With the carbon clearance method, after virus infection, phagocytic activity was slightly increased in the early stages, but decreased gradually during later stages. With the (51)Cr-labelled RBC method, in the early stages, phagocytic activity of liver and spleen was slightly increased and during the later stages accelerated markedly in the liver in contrast to supressed activity in the spleen. It was suggested that an early increase of phagocytic activity observed by both methods was a response to viral infection. Significantly accelerated phagocytic activity seen in the liver during later stages with the (51)Cr method may have been related to the hemolytic anemia associated with Rauscher leukemia.