Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

環境汚染物質(―特に臭素化ベンゼンについて―)の生態系への影響 第5報 1.3.5-トリブロモベンゼンの代謝

荻野 泰夫 岡山大学医学部公衆衛生学教室
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抄録
The formative mechanism of debrominated compounds was investigeted. The excretion rate of tribromobenzene metabolites into the rat urine was enhanced by pretreatment with phenobarbital, and the amount of debrominated bromophenol in urine was greater than that of sulfur containing compounds after phenobarbital pretreatment. on the other hand, sulfur containing compounds were predominant in the urine of rats pretreated with glutathione. Incubation of tribromobenzene with the 10,000g supernatant of rat liver homogenate from rats pretreated with phenobarbital resulted in an increase in 3.5-dibromophenol. The above effect was accelerated remarkably by NADH and NADPH. These results demonstrate two metabolic pathways in the debromination of tribromobenzene: one to sulfur containing compounds and another to bromophenol bodies.
キーワード
1.3.5-トリブロモベンゼン
代謝経路
脱ブロモ化
ISSN
0030-1558
NCID
AN00032489