Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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温泉水飲用の薬物吸収におよぽす影響(インドメタシン,アスピリンの場合)

岡本 輝子 岡山大学医学部附属病院三朝分院
平尾 光宏 岡山大学医学部附属病院三朝分院
古野 勝志 岡山大学医学部附属病院三朝分院
抄録
It is thought that a drug reacts differently with media taken internally. The solubility of Aspirin is assured 600μg/ml in 30min. with Misasa spring water, whereas 400μg/ml with plain water. The parallel difference of 200μg/ml follows 10 min. thereafter. Maximum serum concentratin of 200μg/ml is obtained 2 hours after the internal use of Aspirin with Misasa spring water in parallel difference of 20μg/ml with plain water. In the case of Indomethacin intake, maximum serum concentration of 1.5μg/ml is obtained in 2 hours with plain water, whereas maximum serum concentration of 1μg/ml is obtained in the same period with Misasa spring water. However, the difference of 0.25μg/ml in serum concentration between the media internally taken is seen initially and after 4 hours under high concentration of Indomethacin. We, therefore, assume tentatively that the effect of Aspirin and Indomethacin is supposed to be enhanced with Misasa spring water taken internally.
備考
原著論文 (Original Papers)
ISSN
0369-7142
NCID
AN00032853