Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

<Availability>
Some items are not available because of decision by its author or publisher.

Basophil response to antigen and anti-IgE. 1. Changes in number of basophils.

谷崎 勝朗 岡山大学医学部附属病院三朝分院内科
木村 郁郎 岡山大学医学部第2内科
抄録
Blood basophils in subjects with bronchial asthma migrate from blood stream into local allergic reaction sites after inhalation of antigen into airways. The phenomena can be observed by changes in number of basophils in the peripheral blood. The peripheral basophil count is at a normal level in non-attack stage of asthmatics as in healthy subjects. The basophil count increases in pre-attack stages, and decreases during attack stages. These findings suggest that number of basophils changes in close relation to asthma cycle, and that by observing number of basophils in the peripheral blood, it is possible to detect near future attacks. The decrease in number of basophils and histamine release by stimulation with antigen and anti-IgE can be observed in vitro in whole blood and basophils separated by density gradient centrifugation and by counterflow centrifugation elutriation. The decreased number of basophils in the peripheral blood represents migration of the cells into local allergic reaction sites.
キーワード
basophils (好塩基球)
bronchial asthma (気管支喘息)
asthma cycle (喘息発作)
histamine release (ヒスタミン遊離)
ISSN
0913-3771
NCID
AN10430852