Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

<Availability>
Some items are not available because of decision by its author or publisher.

Basophil response to antigen and anti-IgE 3. Ca(2+) influx and histamine release

谷崎 勝朗 岡山大学医学部附属病院三朝分院
貴谷 光 岡山大学医学部附属病院三朝分院
岡崎 守宏 岡山大学医学部附属病院三朝分院
御舩 尚志 岡山大学医学部附属病院三朝分院
光延 文裕 岡山大学医学部附属病院三朝分院
木村 郁郎 岡山大学医学部第二内科
抄録
The release mechanism of chemical mediators from basophils and mast cells was discussed when these cells were stimulated by different antigens and anti-IgE. 1. Ca(2+) influx into mast cells increased after stimulation by antigen. The increased Ca(2+) uptake by mast cells was inhibited by antiallergic agents, disodium cromoglycate (DSCG) and tranilast, and calcium antagonists, nifedipine and nicardipine. 2. The dose-response curve of histamine release by antigen was different from that by anti-IgE. The maximum release of histamine by house dust was, however, similar to that by anti-IgE. House dust- and anti-IgE-induced release of histamine increased with higher- serum IgE levels. On the contrary, the release of histamine by Candida albicans was not releated to serum IgE levels, and the release by C. albicans did not parallel therelease by anti-IgE.
キーワード
Ca(2+) influx (Ca2+流入)
histamine release (ヒスタミン遊離)
house dust (ハウスダスト)
Candida albicans (カンジダ)
anti-lgE (抗ヒトIgE)
ISSN
0913-3771
NCID
AN10430852