Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Immunosuppression by glucocorticoids leads to bronchoalveolar neutrophilia in patients with bronchial asthma

谷崎 勝朗 岡山大学医学部附属三朝分院内科
貴谷 光 岡山大学医学部附属三朝分院内科
御船 尚志 岡山大学医学部附属三朝分院内科
光延 文裕 岡山大学医学部附属三朝分院内科
梶本 和宏 岡山大学医学部附属三朝分院内科
杉本 啓介 岡山大学医学部附属三朝分院内科
横田 聡 岡山大学医学部附属三朝分院内科
平松 順一 岡山大学医学部附属三朝分院内科
瓦屋 正志 岡山大学医学部附属三朝分院内科
原田 英雄 岡山大学医学部臨床検査医学
木村 郁郎 岡山大学医学部第2内科
抄録
Cellular composition of bronchoalveolar lavage (BAL) fluid was compared between two age-matched steroid-dependent intractable asthma (SDIA) groups : 17 group A patients (serum IgG level < 1000mg/dℓ) whose immunity was regarded as being suppressed by long-term glucocorticoid therapy and 17 group B patients (serum IgG level > 1200mg/dℓ). 1. The levels of serum IgA and IgM were significantly decreased in group A compared to the levels in group B patients. 2. The number of blood lymphocytes was also significantly lower in group A than in group B patients. However, the number of blood neutrophils was not different between the two asthma groups. 3.The number of BAL lymphocytes was significantly lower in group A than in group B patients. 4. BAL neutrophilia (more than 1.5×10 (4)/mℓ) was observed in 6 of the 17(35.3%) patients in group A, but not observed in any patients in group B. The number of BAL neutrophils was significantly greater in group A than in group B patients. These results suggest that there is a correlation between immunosuppression by glucocorticoids and BAL neutrophilia in patients with bronchial asthma.
キーワード
immunosuppression (免疫抑制)
BAL neutrophilia (BAL好中球増多)
glucocorticoids (副腎皮質ホルモン)
bronchial asthma (気管支喘息)
ISSN
0918-7839
NCID
AN10430852