Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Activated blood T cells in patients with bronchial asthma. Relationship to asthmatic cycle.

谷崎 勝朗 岡山大学医学部附属病院三朝分院内科
貴谷 光 岡山大学医学部附属病院三朝分院内科
御船 尚志 岡山大学医学部附属病院三朝分院内科
光延 文裕 岡山大学医学部附属病院三朝分院内科
梶本 和宏 岡山大学医学部附属病院三朝分院内科
杉本 啓介 岡山大学医学部附属病院三朝分院内科
横田 聡 岡山大学医学部附属病院三朝分院内科
平松 順一 岡山大学医学部附属病院三朝分院内科
瓦屋 正志 岡山大学医学部附属病院三朝分院内科
原田 英雄 岡山大学医学部臨床検査医学
多田 慎也 岡山大学医学部第2内科
木村 郁郎 岡山大学医学部第2内科
抄録
The number of CD4(+) T-Iymphocytes, CD4/CD8 ratio, and the number of IL2R(+) T-Iymphocytes (CD25) were examined in 14 patients with bronchial asthma, and the results were compared in three different asthma stages : symptom-free stage, wheeze stage, and attack stage. 1. The proportion of blood CD4(+) T-lymphocytes was more decreased in patients with asthma attacks than in those without symptoms. The CD4/CD8 ratio was also more decreased in patients with attacks than in those without symptoms. However, these differences were not significant. 2. The proportion of blood activated T cells (IL2R(+) cells, CD25) was significantly increased in patients with attacks than in those without symptoms. The proportion of activated T cells in 5 asthma patients was 2.9±0.8% in symptom-free stage and 6.6±1.1% in attack stage(p<0.001). These findings show that numbers of activated T-lymphocytes in peripheral blood were increased during asthma attacks, and this increase suggests the participation of activated T cells in the pathogenesis of asthma.
キーワード
CD4(+) T cells (CD4(+)リンパ球)
CD4/CD8 ratio (CD4/CD8比)
IL2R(+) T cells (IL2R(+)Tリンパ球)
bronchial asthma (気管支喘息)
ISSN
0918-7839
NCID
AN10430852