Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

<Availability>
Some items are not available because of decision by its author or publisher.

Serum immunoglobulin levels and peripheral lymphocyte count related to changes in cellular composition of bronchoalveolar lavage fluid in patients with bronchial asthma

光延 文裕 岡山大学医学部附属病院三朝分院
貴谷 光 岡山大学医学部附属病院三朝分院
御舩 尚志 岡山大学医学部附属病院三朝分院
梶本 和宏 岡山大学医学部附属病院三朝分院
横田 聡 岡山大学医学部附属病院三朝分院
高田 一郎 岡山大学医学部附属病院三朝分院
谷崎 勝朗 岡山大学医学部附属病院三朝分院
越智 浩二 岡山大学医学部臨床検査医学
原田 英雄 岡山大学医学部臨床検査医学
多田 慎也 岡山大学医学部第2内科
原田 実根 岡山大学医学部第2内科
抄録
Changes in airway inflammation by glucocorticoids were examined in 26 patients with bronchial asthma, divided into two age groups ; 20-59 and 60+ years, in relation to serum immunoglobulin levels and peripheral lymphocyte count. 1. The levels of IgG, IgA and IgM were significantly lower in patients with steroid-dependent intractable asthma (SDIA) of age over 60 years than in those with non-SDIA of the same age group. In patients between the ages of 20 and 59, only serum IgG level was significantly lower in SDIA than in non-SDIA patients. 2. Peripheral lymphocyte count was significantly decreased in SDIA patients than in non-SDIA patients in age group over 60, but not in age group between 20 and 59. 3. Number of lymphocytes in bronchoalveolar lavage (BAL) fluid was significantly lower and number of BAL neutrophils was significantly higher in SDIA patients than in non-SDIA patients in age group over 60, but not in age group between 20 and 59. These results suggest that levels of IgG, IgA and IgM, and peripheral lymphocyte count were significantly suppressed in SDIA patients of age over 60, accompanied with decrease of BAL lymphocytes and increase of BAL neutrophils.
キーワード
serum immunoglobulin levels (血清免疫グロブリン値)
lymphocytes (リンパ球)
neutrophils (好中球)
bronchial asthma (気管支喘息)
glucocorticoids (副腎皮質ホルモン)
ISSN
0918-7839
NCID
AN10430852