Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Leukotrienes B4 and C4 generation by peripheral leucocytes in patients with asthma

谷崎 勝朗 岡山大学医学部附属病院三朝分院
光延 文裕 岡山大学医学部附属病院三朝分院
御舩 尚志 岡山大学医学部附属病院三朝分院
保崎 泰弘 岡山大学医学部附属病院三朝分院
芦田 耕三 岡山大学医学部附属病院三朝分院
柘野 浩史 岡山大学医学部附属病院三朝分院
岡本 誠 岡山大学医学部附属病院三朝分院
原田 誠之 岡山大学医学部附属病院三朝分院
湯本 英一郎 岡山大学医学部附属病院三朝分院
高田 真吾 岡山大学医学部附属病院三朝分院
越智 浩二 岡山大学医学部臨床検査医学
原田 英雄 岡山大学医学部臨床検査医学
抄録
The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes stimulated with Ca ionophore A23187 was examined in 16 patients with asthma (8 with atopic and 8 with nonatopic asthma) and 12 healthy controls. 1. The LT84 generation by leucocytes was not significantly different between patients with asthma and healthy controls. The generation of LTC4 was significantly larger in patients with asthma than in healthy controls. The LTC4 generation was also significantly larger in patients with attacks (58.4 ± 38.5 ng/5x10(6) cells) than in those without attacks (23.3 ± 25.9 ng/5x10(6) cells)(p<0.05). 2.ln atopic asthma, the LTC4 production was significantly larger in patients with attacks (84.7 ± 35.4 ng/5x10(6) cells) compared to the production in those without attacks (40.4 ± 27.2 ng/5x10(6) cells)(p<0.02). However, the production of LTB4 was not significantly different between attack and attack-free stages. 3. In nonatopic asthma, the LTC4 production was also significantly higher in patients with attacks (32.2 ± 26.3 ng/5x10(6) cells) than in those without attacks (12.2 ± 3.5 ng/5x10(6) cells)(p<0.05). However, the LTB4 production was not significantly different between attack and nonattack stages. 4. The LTC4 production was significantly larger in atopic asthmatics compared to the production in nonatopic subjects both in attack and nonattack stages. These results suggest that the generation of LTC4 by leucocytes of patients with asthma is closely related to IgE-mediated reaction and asthma attacks.
キーワード
bronchial asthma
LTB4
LTC4
IgE-mediated reaction
asthma attacks
ISSN
0918-7839
NCID
AN10430852