Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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An increase in bronchial hyperresponsiveness by cigarette smoking in elderly patients with asthma

光延 文裕 岡山大学医学部附属病院三朝医療センター 内科
保﨑 泰弘 岡山大学医学部附属病院三朝医療センター リハビリテーション科
芦田 耕三 岡山大学医学部附属病院三朝医療センター 内科
柘野 浩史 岡山大学医学部附属病院三朝医療センター 内科
西田 典数 岡山大学医学部附属病院三朝医療センター 内科
永田 拓也 岡山大学医学部附属病院三朝医療センター 内科
高田 真吾 岡山大学医学部附属病院三朝医療センター 内科
横井 正 岡山大学医学部附属病院三朝医療センター リハビリテーション科
谷崎 勝朗 岡山大学医学部附属病院三朝医療センター 内科
抄録
Influence of cigarette smoking on the pathogenesis of asthma in the elderly remains controversial. This study was undertaken to clarify the influence of cigarette smoking on IgE-mediated allergy, bronchial hyperresponsiveness, and the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leukocytes in 48 elderly patients (25 patients with a history of smoking for more than 20 years and 23 never-smokers) with asthma over the age of 70 years. 1. The incidence of positive IgE antibodies for inhalant allergens was significantly higher in asthmatics with a history of smoking than in never-smokers of asthmatics. 2. In bronchial hyperresponsiveness for methacholine, the Cmin was significantly lower in ever-smokers than in never-smokers of elderly asthmatics. 3. The generation of LB4 was significantly increased in patients with a history of smoking compared with those without a smoking history. However, the difference in LTC4 generation was not significant between ever-smokers and never-smokers of asthmatics. These results suggest that cigarette smoking increases bronchial hyperresponsiceness through IgE-mediated allergy and LTB4 generation.
キーワード
cigarette smoking
IgE - mediated allergy
elderly asthmatics
bronchial hyperresponsiveness
ISSN
1348-1258
NCID
AA11840279