Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Effects of cigarette smoking on IgE-mediated allergy in elderly patients with asthma

芦田 耕三 岡山大学医学部附属病院三朝医療センター 内科
光延 文裕 岡山大学医学部附属病院三朝医療センター 内科
保崎 泰弘 岡山大学医学部附属病院三朝医療センター リハビリテーション科
柘野 浩史 岡山大学医学部附属病院三朝医療センター 内科
西田 典数 岡山大学医学部附属病院三朝医療センター 内科
永田 拓也 岡山大学医学部附属病院三朝医療センター 内科
高田 真吾 岡山大学医学部附属病院三朝医療センター 内科
横井 正 岡山大学医学部附属病院三朝医療センター リハビリテーション科
谷崎 勝朗 岡山大学医学部附属病院三朝医療センター 内科
抄録
The influence of cigarette smoking on the pathophysiology of asthma in the elderly remains controversial. In this study, the inluence of cigarette smoking on IgE - mediated allergy including the generation of leukotrienes B4 (LTB4) and C4 (LTC4) was examined in forty asthmatics over the age of 70 years (20 ex-smokers and 20 never-smokers), and 20 patients with pulmonary emphysema over age 70 (all ex - smokers). The frequency of patients with serum IgE more than 200 IU/ml was significantly larger in smoking asthmatics than in non - smoking asthmatics. The incidence of patients with positive RAST score for inhalant allergens, was also significantly higher in patients with a history of smoking than in those without a smoking history. There were no significant differences in the frequency of patients with positive RAST and those with serum IgE more than 200 IU/ml between non-smoking asthmatics and patients with pulmonary emphysema. The generation of leukotriene B4 (LTB4) by leukocytes was significantly more increased in ex-smokers than in never-smokers in the elderly asthmatics. The results suggest the possibility that cigarette smoking enhances IgE - mediated allergy in elderly patients with asthma.
キーワード
cigarette smoking
IgE - mediated allergy
LTB4
LTC4 generation
elderly asthmatics
ISSN
1348-1258
NCID
AA11840279