Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Cigarette smoking and pathophysiology of asthma and pulmonary emphysema

光延 文裕 岡山大学医学部・歯学部附属病院三朝医療センター 内科
保崎 泰弘 岡山大学医学部・歯学部附属病院三朝医療センター 内科
芦田 耕三 岡山大学医学部・歯学部附属病院三朝医療センター 内科
濱田 全紀 岡山大学医学部・歯学部附属病院三朝医療センター リハビリテーション科
岩垣 尚史 岡山大学医学部・歯学部附属病院三朝医療センター 内科
藤井 誠 岡山大学医学部・歯学部附属病院三朝医療センター 内科
高田 真吾 岡山大学医学部・歯学部附属病院三朝医療センター 内科
谷崎 勝朗 岡山大学医学部・歯学部附属病院三朝医療センター 内科
抄録
The influence of long-term cigarette smoking on the pathophysiology of chronic respiratory diseases with obstructive ventilatory dysfunction was discussed in patients with asthma and pulmonary emphysema (PE). 1. In patients with asthma, significant differences in the pathophysiology of the disease were observed between smokers and nonsmokers. A positive RAST score against inhalant allergens, bronchial hyperresponsiveness, and LTB4 generation by leucocytes were significantly more increased in smokers than in nonsmokers. The values of FEV1/FVC and OLco were significantly more decreased, and % RV was significantly more increased in smokers than in nonsmokers. 2. In comparison of asthma with PE, IgE-mediated allergy was significantly more increased in smokers with asthma than in nonsmokers with asthma and in smokers with PE. The values of % FEV1, FEVl %, and % OLco were significantly higher in nonsmokers with asthma than in smokers with PE, however, the % OLco and % RV were not significantly different between smokers with asthma and those with PE. The % LAA of the lungs on HRCT was larger in patients with PE than in smokers and nonsmokers with asthma. The results suggest that cigarette smoking influences the pathophysiology of asthma and PE.
キーワード
cigarette smoking (喫煙)
pulmonary function (肺機能)
hyperinflation (肺の過膨張)
asthma (喘息)
pulmonary emphysema (肺気腫)
ISSN
1348-1258
NCID
AA11840279