Scientific Reports of the Faculty of Agriculture, Okayama University
Published by the Faculty of Agriculture, Okayama University
ONLINE ISSN : 2186-7755

培養PC 12細胞を用いた神経細胞死誘導法の検討

高畑 京也 岡山大学
井内 砂織 岡山大学
物部 啓一 岡山大学
多田 幹郎 岡山大学
抄録
Rat pheochromocytoma (PC12cells) were recently shown to be a useful model for studying the mechanism of cell death and its prevention by different agents. We show here that the diverse reagents of anticancer drugs, protein kinase C inhibitors, H2o2, and βーamyloid peptides also induce cell death in PC12 cells. Cell death was detected by released activity of lactate dehydrogenase (LDH) from intracellular to medium. These results prompted us to investigate whether cell death in PC12 cells might be induced by different pathways.
キーワード
PC12 cells
neuronal cell death
apoptosis
necrosis
LDH
ISSN
0474-0254
NCID
AN00033029