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ID 17693
Eprint ID
17693
フルテキストURL
Thumnail 88_1067.pdf 3.78 MB
タイトル(別表記)
Neocarzinostatin effect on immune response of mice 2. Effects on cellular immunity
著者
三河内 弘 岡山大学医学部第二内科教室
抄録
In part 2 peripheral lymphocyte count, the total number of spleen cells, the weight and histology of the spleen, in vitro proliferative response of spleen cells to phytohemagglutinin (PHA) and delayed cutaneous hypersensitivity to picryl chloride were studied to see the effects of a new antileukemic agent, Neocarzinostatin (NCS), on the cellular immunity of mice. A single administration of NCS decreased the peripheral lymphocyte count, the spleen weight, the total number of spleen cells and in vitro proliferative response to PHA on the 4(th) and 8(th) day after NCS administration but its suppressive effects on these factors almost disappeared on the 12(th) day. NCS suppressed the delayed cutaneous hypersensitivity to picryl chloride and its suppressive effect was dependent on the daily dose of NCS. But its suppressive effect weakened after 10 days of drug free interval. The above data suggest that NCS suppresses the cellular immunity of mice to a certain degree and its immunosuppressive effects are dependent on the daily dose and the number of consecutive days of NCS administration, and on the days of drug free interval.
発行日
1976-12-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
88巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1067
終了ページ
1078
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/88/11-12/88_11-12_1067/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma