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ID 32101
JaLCDOI
フルテキストURL
著者
Zhang, Shan Okayama University
Takeda, Yoshimasa Okayama University
Hagioka, Shingo Okayama University
Goto, Keiji Okayama University
Morita, Kiyoshi Okayama University
抄録

To elucidate the mechanism by which hyperbaric oxygen (HBO2) induces electrical discharge, changes in the extracellular concentrations of GABA and glutamate were measured every 5 min using a microdialysis technique in rats during a period of exposure to HBO2 (5 atm abs). Electrical discharge was observed at 28 +/- 4 min after the onset of exposure. Though the extracellular concentrations of glutamate remained unchanged, the extracellular GABA concentrations (pre-exposure level, 0.026 +/- 0.005 microM in dialysate) began to decrease 15 min after the onset of exposure and reached their lowest level (74 +/- 14%, 0.019 +/- 0.004 microM) at the time of appearance of the discharge. There was a close logistic relationship between extracellular GABA concentrations and the discharge incidence, and the extracellular concentrations of GABA causing electrical discharge in 50% of the animals were estimated to be 80% of the pre-exposure level. These results suggest a possible mechanism that HBO2 exposure-induced discharge is caused by the decrease in extracellular concentration of GABA.

キーワード
glutamic acid
hyperbaric oxygenation
gamma-aminobutyricacid
microdialysis
seizures
Amo Type
Article
発行日
2004-04
出版物タイトル
Acta Medica Okayama
58巻
2号
出版者
Okayama University Medical School
開始ページ
91
終了ページ
95
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT