このエントリーをはてなブックマークに追加
ID 46944
フルテキストURL
著者
Ishimoto, Hidekazu Department of Pharmacognosy, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Shibata, Mari Department of Pharmacology, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Myojin, Yuki Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Okayama University
Ito, Hideyuki Department of Pharmacognosy, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Sugimoto, Yukio Department of Pharmacology, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Tai, Akihiro Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima
Hatano, Tsutomu Department of Pharmacognosy, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
抄録
Urolithin A is a major metabolite produced by rats and humans after consumption of pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the anti-inflammatory effect of urolithin A on carrageenan-induced paw edema in mice. The volume of paw edema was reduced at 1 h after oral administration of urolithin A. In addition, plasma in treated mice exhibited significant oxygen radical antioxidant capacity (ORAC) scores with high plasma levels of the unconjugated form at 1 h after oral administration of urolithin A. These results indicate strong associations among plasma urolithin A levels, the plasma ORAC scores, and anti-inflammatory effects and may help explain a mechanism by which ellagitannins confer protection against inflammatory diseases.
キーワード
Ellagitannin
Urolithin A
Antioxidant activity
Anti-inflammatory activity
発行日
2011-10-01
出版物タイトル
Bioorganic & Medicinal Chemistry Letters
21巻
19号
出版者
Pergamon-Elsevier Science Ltd.
開始ページ
5901
終了ページ
5904
ISSN
0960-894X
NCID
AA1079577X
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© 2011 Elsevier Ltd. All rights reserved.
論文のバージョン
author
査読
有り
DOI
PubMed ID
Web of Sience KeyUT