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ID 41323
JaLCDOI
フルテキストURL
Thumnail 64_6_375.pdf 1.16 MB
著者
Kariya, Shin Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Cureoglu, Sebahattin International Hearing Foundation
Fukushima, Hisaki Department of Otolaryngology, Kawasaki Medical School
Morita, Norimasa Department of Otolaryngology, Kawasaki Medical School
Baylan, Muzeyyen Y. Department of Otolaryngology-Head & Neck Surgery, University of Minnesota
Maeda, Yukihide Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nishizaki, Kazunori Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Paparella, Michael M. International Hearing Foundation
抄録
This study examined whether pathological findings were present in cochlear vessels for patients with diabetes mellitus. Twenty-six temporal bones from 13 patients with type 1 diabetes mellitus and 40 temporal bones from 20 patients with type 2 diabetes mellitus were examined. Type 2 diabetic temporal bones were divided into 2 groups according to diabetic management (22 temporal bones with insulin therapy, and 18 with oral hypoglycemic drugs). Age-matched normal control temporal bones were also selected. The vessel wall thickness in the cochlear spiral modiolar artery was measured under a light microscope, and the vessel wall ratio (vessel wall thickness/outer diameter of the vessel×100) was calculated. The vessel wall thickness and vessel wall ratio in type 1 diabetes mellitus were significantly greater than in normal controls. Type 2 diabetic patients with insulin therapy showed significantly greater vessel wall thickness and vessel wall ratios than controls. In type 2 diabetes mellitus, the vessel wall thickness and vessel wall ratio were greater in patients treated with insulin therapy than in those treated with oral hypoglycemic agents. Type 2 diabetic patients with insulin therapy showed an increased vessel wall thickness and vessel wall ratio compared to patients with type 1 diabetes mellitus. In conclusion, the cochlea in patients with diabetes mellitus shows circulatory disturbance compared to age-matched normal controls.
キーワード
diabetes mellitus
temporal bone
cochlear spiral modiolar artery
hearing loss
Amo Type
Original Article
発行日
2010-12
出版物タイトル
Acta Medica Okayama
64巻
6号
出版者
Okayama University Medical School
開始ページ
375
終了ページ
383
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT