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ID 48707
フルテキストURL
著者
Kataoka, Takahiro Graduate School of Health Sciences, Okayama University
Sakoda, Akihiro Graduate School of Health Sciences, Okayama University
Ishimori, Yuu Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Toyota, Teruaki Graduate School of Health Sciences, Okayama University
Nishiyama, Yuichi Graduate School of Health Sciences, Okayama University
Tanaka, Hiroshi Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Mitsunobu, Fumihiro Misasa Medical Center, Okayama University Hospital
Yamaoka, Kiyonori Graduate School of Health Sciences, Okayama University
抄録
We examined dose–dependent or dose rate–dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m3 for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2000 day•Bq/m3, activation of SOD activities in plasma, liver, pancreas, heart, thymus, and kidney showed dose–rate effects. Our results also suggested that continuous exposure to radon increased SOD activity, but SOD activity transiently returned to normal levels at around 2 days. Moreover, we classified the organs into four groups (1. plasma, brain, lung; 2. heart, liver, pancreas, small intestine; 3. kidney, thymus; 4. stomach) based on changes in SOD activity. Thymus had the highest responsiveness and stomach had lowest. These data provide useful baseline measurements for future studies on radon effects.
キーワード
Radon
Superoxide dismutase
Dose
Dose rate
Large-scale facility
発行日
2011-11-22
出版物タイトル
Journal of Radiation Research
52巻
6号
出版者
Journal of Radiation Research Editorial Committee
開始ページ
775
終了ページ
781
ISSN
0449-3060
NCID
AA00705792
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/jrr/52/6/52_10072/_article
言語
English
著作権者
Copyright © 2011 by Journal of Radiation Research Editorial Committee
論文のバージョン
publisher
査読
有り
DOI
PubMed ID
Web of Sience KeyUT