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ID 17155
Eprint ID
17155
フルテキストURL
Thumnail 89_749.pdf 315 KB
タイトル(別表記)
Effect of biscoclaurin alkaloids of the biomembrane system and its action mechanisms Part I. Inhibitory effects of cepharanthine on the K(+)-release after the injury to cell membrane
著者
宮原 正信 岡山大学医学部第一病理学教室
内海 耕慥 岡山大学医学部附属癌源研究施設生化学研究部門
杉山 勝三 岡山大学医学部薬理学教室
青野 要 岡山大学医学部附属病院中央放射線部
抄録
Concerining the physiological properties possessed by the cell membrane, recently an attention has been called on various problems such as the cell recognition mechanism to begin with, and the mutual relationships among the intercellular communication mechanism, as well as the metabolism adjustment of membrane binding enzymes, aside from the compartmentation of substances. Essentially the physico-chemical properties of the membrane of cancer cell and proliferating cells are important in relation to the treatment of cancer. And attempts are being made to change the cell metabolism by artificially altering the physicochemical properties of the cell membrane. Cepharanthine, one of the biscoclaurin alkaloids, is known from olden days to possess a thanatophidia hemolytic property, but this property seems to bring about the change in the physico-chemical properties of the cell membrane, and it is interesting in the point that this substance may have a membrane modifying property. For these reasons, during the investigation on the actions of alkaloids on the cell membrane many interesting phenomena have been elucidated. This report presents the results recently obtained about the changes in physico-chemical properties of biological membrane by the treatment with cepharanthine. The obtained results were as follows. 1. Cepharanthine inhibits K(+)-release from red blood cells when these cells are treated with snake venom, phospholipase A, lysolecithine, lead acetate and hexane. But the alkaloid does not inhibit K(+)-release induced by ionophores, surface active agents and HVJ. 2. Cepharanthine inhibits the hyperpolalization of membrane potential induced by lead acetate or hexane. 3. Similar inhibitory effect of cholesterol on K(+)-release from the cells by the treatment with lead acetate is observed. 4. From these results it is suggested that the inhibitory action of cepharanthine on K(+)-release from cells is due to the action of decrease in membrane fluidity.
発行日
1977-08-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
89巻
7-8号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
749
終了ページ
756
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/89/7-8/89_7-8_749/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma