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en-title=バスピン血中濃度はインスリン抵抗性と相関があり、日本人にはrs77060950によって規定される血中濃度高値群が存在する
kn-title=Serum Vaspin Concentrations Are Closely Related to Insulin Resistance, and rs77060950 at SERPINA12 Genetically Defines Distinct Group with Higher Serum Levels in Japanese Population
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en-aut-name=TeshigawaraSanae
en-aut-sei=Teshigawara
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affil-num=1
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kn-affil=岡山大学
END

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en-title=Collectrin is involved in the development of salt-sensitive hypertension by facilitating the membrane trafficking of apical membrane proteins via interaction with soluble n-ethylmaleiamide-sensitive factor attachment protein receptor complex
kn-title=コレクトリンはSNARE複合体との相互作用を介して管腔側膜蛋白の膜輸送を促進し食塩感受性高血圧の発症に関与している
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en-aut-name=YasuharaAkihiro
en-aut-sei=Yasuhara
en-aut-mei=Akihiro
kn-aut-name=安原章浩
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kn-aut-mei=章浩
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en-aut-name=WadaJun
en-aut-sei=Wada
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kn-aut-name=和田淳
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en-aut-name=EguchiJun
en-aut-sei=Eguchi
en-aut-mei=Jun
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en-aut-name=NakatsukaAtsuko
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en-aut-name=MurakamiKazutoshi
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en-aut-name=KanzakiMotoko
en-aut-sei=Kanzaki
en-aut-mei=Motoko
kn-aut-name=神崎資子
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en-aut-name=TeshigawaraSanae
en-aut-sei=Teshigawara
en-aut-mei=Sanae
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en-aut-name=MakinoHirofumi
en-aut-sei=Makino
en-aut-mei=Hirofumi
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kn-aut-sei=槇野
kn-aut-mei=博史
aut-affil-num=8

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学

affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学
en-keyword=食塩感受性高血圧
kn-keyword=食塩感受性高血圧
en-keyword=コレクトリン
kn-keyword=コレクトリン
en-keyword=集合管
kn-keyword=集合管
en-keyword=SNARE複合体
kn-keyword=SNARE複合体
en-keyword=ナトリウム再吸収
kn-keyword=ナトリウム再吸収
citation=1) Zhang H, Wada J, Hida K, Tsuchiyama Y, Hiragushi K, Shikata K, Wang H, Lin S, Kanwar YS, Makino H : Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys. J Biol Chem (2001) 276, 17132-17139. 
citation=2) Fukui K, Yang Q, Cao Y, Takahashi N, Hatakeyama H, Wang H, Wada J, Zhang Y, Shimomura I, Miyagawa J, Wollheim CB, Yamagata K, et al. : The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Cell Metab (2005) 2, 373-384. 
citation=3) Akpinar P, Kuwajima S, Krutzfeldt J, Stoffel M : Tmem27 : a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation. Cell Metab (2005) 2, 385-397. 
citation=4) Malakauskas SM, Quan H, Fields TA, McCall SJ, Yu MJ, Kourany WM, Frey CW, Le TH : Aminoaciduria and altered renal expression of luminal amino acid transporters in mice lacking novel gene collectrin. Am J Physiol Renal Physiol (2007) 292, F533-544. 
citation=5) Danilczyk U, Sarao R, Remy C, Benabbas C, Stange G, Richter A, Camargo SM, Makrides V, Ramadan T, Verrey F, Wagner CA, Penninger JM, et al. : Essential role for collectrin in renal amino acid transport. Nature (2006) 444, 1088-1091. 
citation=6) Zhang Y, Wada J, Yasuhara A, Iseda I, Eguchi J, Yamagata K, Hiesberger T, Igarashi P, Zhang H, Akagi S, Kanwar YS, Makino H, et al. : The role for HNF-1beta-targeted collectrin in maintenance of primary cilia and cell polarity in collecting duct cells. PLoS ONE (2007) 2, e414. 
citation=7) Pontoglio M, Barra J, Hadchouel M, Doyen A, Kress C, Bach JP, Babinet C, Yaniv M : Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome. Cell (1996) 84, 575-585. 
citation=8) Yu HC, Burrell LM, Black MJ, Wu LL, Dilley RJ, Cooper ME, Johnston CI : Salt induces myocardial and renal fibrosis in normotensive and hypertensive rats. Circulation (1998) 98, 2621-2628. 
citation=9) McBride SM, Culver B, Flynn FW : Prenatal and early postnatal dietary sodium restriction sensitizes the adult rat to amphetamines. Am J Physiol Regul Integr Comp Physiol (2006) 291, R1192-1199. 
citation=10) Pittman DW, Contreras RJ : Dietary NaCl influences the organization of chorda tympani neurons projecting to the nucleus of the solitary tract in rats. Chem Senses (2002) 27, 4, 333-341. 
citation=11) Griffin KA, Churchill PC, Picken M, Webb RC, Kurtz TW, Bidani AK : Differential salt-sensitivity in the pathogenesis of renal damage in SHR and stroke prone SHR. Am J Hypertens (2001) 14, 311-320. 
citation=12) Mandon B, Chou CL, Nielsen S, Knepper MA : Syntaxin-4 is localized to the apical plasma membrane of rat renal collecting duct cells : possible role in aquaporin-2 trafficking. J Clin Invest (1996) 98, 906-913. 
citation=13) Banerjee A, Li G, Alexander EA, Schwartz JH : Role of SNAP-23 in trafficking of H+-ATPase in cultured inner medullary collecting duct cells. Am J Physiol Cell Physiol (2001) 280, C775-781. 
citation=14) Nagase M, Matsui H, Shibata S, Gotoda T, Fujita T : Salt-induced nephropathyin obese spontaneously hypertensive rats via paradoxical activation of the mineral-ocorticoid receptor : role of oxidative stress. Hypertension (2007) 50, 877-883.
END