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ID 21215
Eprint ID
21215
フルテキストURL
タイトル(別表記)
Studies on lithium in the field of balneology : Effects of lithium salts on analgesic activity of aminopyrine
著者
古野 勝志 岡山大学温泉研究所温泉医学部門
御船 政明 岡山大学温泉研究所温泉医学部門
抄録
The authors studied the effect of pretreatment with internal use of lithium salts on analgesic activity of aminopyrine by hot-plate test in mice. The male mice at 4 weeks of age weighting 17-19 g were divided into 7 groups. Earch group being composed of 9-10 mice was given oraBy 0.1 ml of LiCI-solution per 10 g of body weight for 35 days, LiCl was dissolved in 0.9% saline solution, in such concentrations that each group received 0 mg, 50 mg, 100mg, 200 mg and 400mg of LiCl for each kg of body weight of mouse, respectively, Control group received only 0.9% saline solution. On the 1st, 3rd, 7th, 14th, 21st, 28th and 35th days of this experiment, 0.1 ml of 1% solution of aminopyrine per 109 of body weight was injected intraperitoneaJly and then tested 30 minutes later. In the hot-plate test, a mouse is placed on a hot plate being adjusted with the thermostat at 55°±1℃, and the response is licking or lifting the hind feet or an outright attempt to escape from the plate, The increase in response time is used to quantify the analgesic effect of aminopyrine, The results were as follows : 1. The response time in groups receiving 0-50 mg of LiCl per kg of body weight had decreased on the 14 th day, but it tended to return to the initial level after the 21st day of experiment. 2. The response time in groups receiving 100-400 mg of LiCl per kg of body weight had also decreased on the 14 th day, and the degree of the decrease in response time was greater than that of the former and then remained faily constant at this level to the end of the observation period. These results would indicate that LiCl inhibits the analgesic activity of aminopyrine.
備考
原著論文 (Original Papers)
発行日
1976-03-25
出版物タイトル
岡山大学温泉研究所報告
出版物タイトル(別表記)
Papers of the Institute for Thermal Spring Research, Okayama University
45巻
出版者
岡山大学温泉研究所
出版者(別表記)
Institute for Thermal Spring Research, Okayama University
開始ページ
25
終了ページ
31
ISSN
0369-7142
NCID
AN00032853
資料タイプ
紀要論文
言語
Japanese
論文のバージョン
publisher
査読
無し
Eprints Journal Name
mmc