岡山医学会 Acta Medica Okayama 0030-1558 69 8 1957 無尿，乏尿に対する塩酸プロカイン静注療法に関する実験的研究 第一編 清掃法による研究 1973 1982 EN Masahiko Furumoto The author has studied on the effect of intravenous HCl-procaine treatment for oliguria caused by hemolyzed blood administration, anestesia, operation, burn and corrosive sublimate intoxication, by means of renal clearance method. 1. The clearance level fell down in every case manipulated as above, and it was remarkable especially in the cases of burn and corrosive sublimate intoxication. 2. For these kidney insufficiencies intravenous HCl-procaine administration had result of restoring the urinary quantity, approximately up to 100% in every case. 3. By that treatment the urea clearance showed marked improvement, renal blood flow and glomerular filtration rate were increased from 10 to 100% in every case. 4. Those effects were remakable in the case of hemolyzed blood administration, anesthesia and especially in burn case, but were not expectable in the case of operation and corrosive sublimate intoxication. because of the extreme burden and of the marked organic changes in rabbits respectively. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 69 8 1957 無尿，乏尿に対する塩酸プロカイン静注療法に関する実験的研究 第二編 腎血管内墨汁注入法による研究 1983 1995 EN Masahiko Furumoto The author has studied on the effect of intravenous HCl-procaine treatment exmining the renal vascular patterns, for the lesions caused by hemolyzed blood administration, burn and intramuscular corrosive sublimate injection, by utilizing the Indian-ink infusion method. 1. In the kidneys of rabbits administered hemolyzed blood and burned the cortical arteries contracted, and following by the ischemia; the blood flow diverted to the juxtamedullary glomerulus and subcortical zone and Oxford shunting was observed. 2. For these conditions intravenous HCl-procaine administration had result of restoring the ischemia after dilatation of cortical arteries, increase of the cortical blood flow and disappearance of the various shunting. 3. In the case of intramuscular injection of the corrosive sublimate the effect of this method was not striking, because of marked changes in the glomerulus and in the tubulus. The author concludes, obtaining these results, that the above described treatment for anuria and oliguria after surgical invasion could be recommended by all means. No potential conflict of interest relevant to this article was reported.