JaLCDOI 10.18926/21102
タイトル(別表記) Research for carbon dioxide bathing IV, Thermal effect of artificial CO(2)-bathing
フルテキストURL 054_001_012.pdf
著者 萬 秀憲| 久保 裕一郎| 江口 泰輝| 砂川 満| 河本 知二| 古元 嘉昭| 古元 順子|
抄録 1) 炭酸塩と,コ-ク酸からなる錠剤型の「炭酸ガス浴剤」の保温作用を健康な男子8名について,サ-モグラフィーを用いて測定した. 入浴10分後の比較で明らかに,炭酸ガス浴はよく温まった結果,表面温度が高くなっている. 2) 腰痛,四肢冷感,その他の患者24名での臨床評価の結果,患者の90%以上が手足が温まり,湯ざめしにくいことを認めた.また,患者の85%は痛みがやわらぐことを認めた. 3) 主婦664名を対象とした使用評価の結果,常時手足の冷感を訴える者の63.6%,身体の疲労感・だるさ56.5%に効果を認めていることがわかった. 4) 副作用は全く認められなかった.
抄録(別表記) The artificial CO(2)-bath was prepared with a tablet (50g), made from sodium bicarbonate and succinic acid, putting simply in plain water bathtub of 150-200 litre at 40℃. Thermal effect was evaluated by means of thermography in healthy 8 men; temperature areas of 34.5℃ or greater were recorded in average compared to a plain bathing and to an artificial Na(2)SO(4)-NaHCO(3) one 10 minutes later. Clinical evaluation by questionnairings of 24 patients suffering mainly from lumbago and 4-extremity coldness revealed a long lasting peripheral warmth in 90% and the ease from pain in 85%. The artificial CO(2)-bathing was effective for women whose health were adversely affected by the cold in 63.6% and for general fatigue or dullness in 56.5% of 664 female volunteers whom the questionnairings were conducted to. No side effect was encountered in the survey.
出版物タイトル 岡山大学温泉研究所報告
発行日 1984-03-25
54巻
開始ページ 1
終了ページ 12
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
JaLCDOI 10.18926/19630
タイトル(別表記) The effect of artificial CO(2) bathing on peripheral circulation insufficiency.
フルテキストURL 057_003_008.pdf
著者 古元 嘉昭| 河本 知二| 砂川 満| 萬 秀憲| 江口 泰輝|
抄録 末梢動脈の慢性閉塞性疾患に対する血行再建術の予後は不良で,虚血肢の治療には一定の見解が乏しく非常に難澁するものである。組織循環の概念にもとづいた評価法によると,医用質量分析装置を用いた虚血肢運動負荷後のPtCO(2)の脱飽和曲線の型により組織循環の良否が定まる。組織循環の良好な型では,自然予後は良好で,いかなる保存的治療にもよく反応する。一方,組織循環の不良な型の自然予後は不良であるので,人工炭酸泉浴によるPtO(2)の増加,および組織循環量の改善により予後は良好となる。人工炭酸泉浴は,組織循環の良好な症例には治癒促進的に作用し,組織循環の不良な症例にも有効に作用する。
抄録(別表記) Arteriography provides clear and useful information of ischemic leg anatomy. The method is limited, in that measurement of less than 100μ can not be made. The hemodynamics or functional consequences of the ischemic state should be evaluated by tissue circulation or perfusion methods that depend principally on systemic blood flow. Tissue perfusion is classified in two groups, insufficient and sufficient, depending on the type of clearance curve of PCO(2) in leg muscle following ankle exercise by means of medical mass spectrometry, Medspect Ⅱ, Chemetron, U.S.A. Either artificial CO(2) bathing or CO(2) vapour bath are efficacious for peripheral ischemic wound. Artificial CO(2) bathing is prepared with BUB-KAO 2tab., a 50g sodium hydrogen-carbonate and succinic acid tablet, Kao Co. Ltd. Japan, in 280-litre-tub at 40℃ for 20 minutes. CO(2) vapour bath is prepared with UKS CO(2) Trockengas Badkabine, Hansen Co., Ltd. West Germany, 20-litre-CO(2) per minutes at 40~42℃ for 20 minutes. In the case of insufficient tissue perfusion, ischemic wound is met promising outcome with CO(2) bathing even though no hope is expected with any medicine for peripheral circulation. Whereas, in the case of sufficient tissue perfusion, ischemic wound is expected much help of CO(2) bathing, as well as of all kinds of medicine, in healing process.
キーワード 人工炭酸浴 (Artificial CO(2) bath) 連浴 (serial bathing) 末梢循環障害 (peripheral circuiation insufficiency) 医用質量分析装置 (medical mass spectrometer) 組織循環 (tissue perfusion)
出版物タイトル 環境病態研報告
発行日 1986-07
57巻
開始ページ 3
終了ページ 8
ISSN 09133771
言語 Japanese
論文のバージョン publisher
JaLCDOI 10.18926/40154
タイトル(別表記) Report of a case of severe mechanical joundice -Successfully treated by jejuno-hepatic ducts anastomoses
フルテキストURL 041_057_062.pdf
著者 野一色 泰晴| 小竹森 通明| 古元 嘉昭| 仲原 泰博|
抄録 Jejuno hepatic ducts anastomoses were successfully performed by carefull managements. Because of dense adhesion at hilus of liver, around the gall bladder and choledocus, dissection of common duct, cystic duct, hepatic ducts and even gall bladder was very difficult anatomically. Resecting a inflammatory granulative tumor, including gall bladder, choledocus, lesser omentum and hepatocluodenal ligament en mass, we found that only very short hepatic ducts with inflammatory granulation tissue were remained open. Reconstruction of biliary passages was done using Roux. Y. method with loop jejunum. It needed very carefull procedure to avoid suture failure, ascending infection (cholangitis) and postoperative stenoses at the site of the anastomoses. The anastomoses were performed using atraumatic 3-0 Tefdek ; interrupted and each big bite of duct wall together with surrounding thickend granulative tissue, in order to keep capillary blood supply effective and to minimize the anastomotic trauma which were very important for wound healing. Patient is healthy, enjoying his normal life and his liver function tests are within normal range, 1 1/2 years postoperatively.
出版物タイトル 岡山大学温泉研究所報告
発行日 1972-03-25
41巻
開始ページ 57
終了ページ 62
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 40017532304
JaLCDOI 10.18926/40155
タイトル(別表記) Esophagus hiatal hernia with special reference to the early stage
フルテキストURL pitsr_041_063_068.pdf
著者 野一色 泰晴| 古元 嘉昭| 仲原 泰博|
抄録 In the aged, hiatal hernia should be recognized as it has developed; it develops progressively. Special attention should be given to the early stage of hiatal hernia from the genetic point of view. Like other organs in the aged, aging changes around a hiatus are inevitable; relaxing of esophageal diaphragmatic ligament and weakening of muscle power of diaphragmatic vertebral part move on with age. After all, valve structure at hiatus, Goubaroff's valve, is so weakened its function and in the stomach, "His angle" is so widened, that the stomach becomes wedge shaped against the hiatus. The more the pressure in the stomach increases, the larger the wedge shapes. Under these conditions, when the abdominal pressure rises by the acts of coughing or defecation, hiatus may be widened and the wedge may be pushed into the hiatus. There are no strong valve and or ligament enough to keep the wedge part of stomach in peritoneal cavity. In the stomach, the pressure of the expelling meal is equal to that of the widening wedge. On the other hand, in the peritoneal cavity, pressure produced by the act of defecation is equal to that of ejecting the wedge through hiatus. These are self-evident from the Pascal's principle. Hiatal hernia is produced under these conditions. We, therefore, should call the attention to the early genetic stage of hiatal hernia. In Japan, hiatal hernia has been recognized when it gets larger and fixes out of the peritoneal cavity. But in the early stage, it also must be noted as hiatal hernia.
出版物タイトル 岡山大学温泉研究所報告
発行日 1972-03-25
41巻
開始ページ 63
終了ページ 68
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002398151
JaLCDOI 10.18926/21228
タイトル(別表記) Continuous in-vIvo measurement of the brain tissue and the ischemic muscle gas tension using MEDSPECT, MS-8
フルテキストURL pitsr_043_029_036.pdf
著者 川上 俊爾| 山根 義久| 野一色 泰晴| 古元 嘉昭| 寺本 滋| 妹尾 嘉昌| 金子 克也| 杉本 誠起| 高橋 俊二郎|
抄録 I MEDSPECT is a medical mass spectrometer for continuous in-vivo measurement of tissue, blood and respiratory gases. Interfacing catheter for tissue in measurement has Teflon membrane. The permeability and perfusion rate for various gases through its membrane varied with temperature. The temperature coefficient of Teflon catheter in the range of 15℃-40℃ is approximately constant with -2% of correction per degree for oxygen and carbon dioxide. Linear correlation was confirmed experimentally. II The brain tissue gas tensions were measured in ten dogs with intra-venous anesthesia at normothermia and deep hypothermia using perfusion cooling, including circulatory arrest for 30 minutes at 20°C of cerebral temperature. On average, the brain tissue P(O2) was 15mmHg in normothermia when the arterial P(O2) showed 95mmHg and the brain tissue P(CO2) was 49mmHg when the arterial PC02 showed 30mmHg. The brain tissue carbon dioxide tension gradually decreased by cooling and increased during circulatory arrest for 30 minutes; from 45mmHg to 72mmHg. The brain tissue oxygen tension increased during cooling from 15mmHg to 41mmHg and decreased in the circulatory arrest; from 41mmHg to 36mmHg. III The ischemic muscle gas tension was measured in a 22-year-old man, who was suffered from thromboangiitis obliterans bilaterally, and had the popliteal autovein bypass surgery 3 months ago. Control oxygen tensions in the both anterior tibial muscles showed about the same; 35mmHg and 36mmHg respectivelly, and the P(O2) of the non-operated side showed remarkable low level of 18mmHg as compared with the side of arterial reconstruction surgery after 5-minutes ankle exercise.
出版物タイトル 岡山大学温泉研究所報告
発行日 1974-03-25
43巻
開始ページ 29
終了ページ 36
ISSN 0369-7142
関連URL http://eprints.lib.okayama-u.ac.jp/21235
言語 Japanese
論文のバージョン publisher
NAID 120002311036
JaLCDOI 10.18926/21137
タイトル(別表記) An Experience of the "Thermalstollenkur" in Böckstein-Badgastein, Austria
フルテキストURL pitsr_052_039_044.pdf
著者 古元 嘉昭| 古元 順子|
抄録 The balneotherapeutic tunnel of Radha usberg is located in Badgastein 1280 meter above the sea level and was instituted to offer a new and unique thermal therapy in 1954. The ther mal therapy is performed for a period of 8 months from February to October seasonally on patients of more than 35,000 from all over the world. The information given by chief Dr. Beate Sandri is summarized as follows; There are 3 cooperative acting factors such as the heat inside the tunnel of 37.5-41.5℃, high humidity and high content of Radon. They stimulate a pituitary - adrenocortical system enough to sedate the vicious circle of pain pathology and to improve a peripheral tissue perfusion. This balneotherapy is completed preferably in combination with massage and exercise, and is repeated in each season with patience. The indications are as follows; 1. chronic rheumatic arthritis, 2. degenerative arthrosis, 3. collagen diseases, 4. gout, 5. peripheral vascular diseases, 6. posttraumatic disorders, 7. central and peripheral nerve disorders, 8. allergic diseases, 9. hormonal and autonomic nerve disorders. Cure effect is evaluated by the improvement of subjective symptoms such as relief from pain, extension of the range of movement, increase of daily activities and so on, regardless of the pathology of each joint. The balneotherapy aims to stimulate patients' own abilities, so that the potential curability of the patients is set forth as a premise; so called end stage patients are beyond the remedy as Prof. Scheminzky insists.
出版物タイトル 岡山大学温泉研究所報告
発行日 1982-03-25
52巻
開始ページ 39
終了ページ 44
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002310983
JaLCDOI 10.18926/21115
タイトル(別表記) Hypnotic effect of the peloid therapy applied on the right hypochondrium in reference to plasma L-tryptophan
フルテキストURL pitsr_053_009_011.pdf
著者 森永 寛| 古元 順子| 古元 嘉昭|
抄録 Based on the EEG-observation of falling asleep when patients are under peloid therapy applied on the right hypochondrium, following assumption is made to clarify the mechanism of inducing sleep. While patients are under the peloid therapy, some chemical substance will be produced in circulating blood; L-tryptophan, an essential amino acid and a precursor of serotonin, gets over a blood-brain barrier easily to induce sleep. Six healthy volunteers, each sex by threes, were selected to apply peloid pack on the right hypochondrium for 30 minutes following 12-hour fasting. Significant increase in plasma L-tryptophan level was obtained in the clinical experiment. It is speculated from the preliminary data that L-tryptophan increased by the peloid therapy may possibly act as a specific physiological hypnotics.
出版物タイトル 岡山大学温泉研究所報告
発行日 1983-03-25
53巻
開始ページ 9
終了ページ 11
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002311031
JaLCDOI 10.18926/21082
タイトル(別表記) The effect on tissue perfusion by brine spring (solquellen)
フルテキストURL pitsr_056_013_016.pdf
著者 古元 嘉昭| 河本 知二| 砂川 満| 古元 順子|
抄録 Changes in partial pressures of each tissue gas and tissue perfusion were evaluated in the 2.5% artificial salt baths by means of medical mass spectrometry using 9 rabbits. The level of subcutaueous PO(2) lowered by 18% and PCO(2) elevated by 7 % compared with the plain water bath. The tissue perfusion volume was found increased by few %. It is assumed that we owe the warm feeling after taking concentrated salt baths to the improved tissue perfusion.
出版物タイトル 岡山大学温泉研究所報告
発行日 1985-03-30
56巻
開始ページ 13
終了ページ 16
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002311012
JaLCDOI 10.18926/21081
タイトル(別表記) An application of the artificial CO(2) bath for enuresis
フルテキストURL pitsr_056_009_011.pdf
著者 古元 順子| 古元 嘉昭|
抄録 The artificial CO(2) bath was prescribed for two enuretic boys with bladder-sensitive or parasympaticotonic type. A tablet of 50 g, made from sodium bicarbonate and succinic acid, was put in a bath-tub of 150-200 L at 40℃. Each patient was recommended to take a bath with his mother longer than ten minutes, and to mark the presence or the absence of enuresis every day. Outcome results of case 1 on CO(2) bath is shown in tabel 1 and results of case 2 on CO(2) bath is shown in table 3. Both two cases became free from enuresis 7-10 days after the initiation of the artificial CO(2) bathing. Etiological mechanisms of enuresis seem to be multi-factorious, with underlining networks of central- and autonomous nerve systems for the control of sleep and bladder. It is suspected that some improvement of peripheral circulation by CO(2)-bathing leading to keep the body warm may be one of the contributing factors which prolong the intervals of urination, resulting in autonomous normalization, at least, for the cases of bladder-sensitive enuresis, Further case studies are needed to support this assumption.
出版物タイトル 岡山大学温泉研究所報告
発行日 1985-03-30
56巻
開始ページ 9
終了ページ 11
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002310958
JaLCDOI 10.18926/19828
タイトル(別表記) A case report of linitis plastica type of colon cancer.
フルテキストURL 060_094_099.pdf
著者 平井 俊一| 鈴鹿 伊智雄| 森末 慎八| 曽田 益弘| 得能 輝男| 古元 嘉昭| 砂川 満| 萬 秀憲| 大塚 昭雄|
抄録 原発性びまん浸潤型大腸癌は,全大腸癌症例の1%未満と比較的稀な疾患であり,一般大腸癌症例とくらべてその予後の悪いことで知られている。その原因の一つとして,確定診断の困難さがあるが,これは粘膜病変の欠如のために生検で確論がつきにくい点にある。我々の症例は,43歳の女性で,横行結腸に原発した症例である。腹痛を訴えて入院後,急速にイレウス状態となり,注腸検査で横行結腸の高度な狭窄を認めた。大腸ファイバースコープは腹痛のため病変部まで届かず,膣擦過細胞診およびダグラス窩穿刺腹水細胞診にて腺癌細胞を確認できた。手術所見はP(3)H(0)S(3)N(4)で,姑息切除に終わった。本症は手術時の進行度がきわめて高度であるので,本症を疑って確診のつかない症例には,上記のような細胞診も試みてみるべきと思われる。
抄録(別表記) A 43-year-old women, complaining of abdominal pain and menstrual irregularity was found suffering from adenocarcinoma of the transverse colon by cytology tests for vaginal smear and ascites. She was operated for colonic obstruction palliatively because of the extensive lesions and died 2 months after surgery for all that of the intensive cancer therapy. The histological diagnosis was primary linitis plastica type of carcinoma of the transverse colon. Carcer involvement to the ovaries and uterine tubes could possibly be responsible for the positive cytology test for vaginal smear. This rare type of careinoma demonstrates certain clinicopathological characteristics that differ from those of the ordinary colonic carcinomas, such as unfavourable prognosis with the difficulty for diagnosis due to minimal mucosal changes and the marked thickend wall of the tumor being unable to perform endoscopic studies.
キーワード びまん浸潤型大腸癌 スキルス大腸癌 (Scirrhous Carcinoma of the Colon) Ⅳ型大腸癌 Linitis Plastica型大腸癌 (Linitis Plastica Type of Carcinoma)
出版物タイトル 環境病態研報告
発行日 1989-07
60巻
開始ページ 94
終了ページ 99
ISSN 09133771
言語 Japanese
論文のバージョン publisher
NAID 120002309174
JaLCDOI 10.18926/19817
タイトル(別表記) Radiation horrnesis with Radon baths
フルテキストURL 060_072_075.pdf
著者 古元 嘉昭| 得能 輝男| 曽田 益弘| 平井 俊一| 森末 真八| 鈴鹿 伊智雄| 砂川 満| 萬 秀憲|
抄録 ラドン泉浴の保温作用は,薬効的には高濃度(13,764-23,743Bq/ℓ)ラドンの吸入による組織循環の改善による。ラドンによる脈管作動的機序はなお明らかにし得ていないが,末梢循環改着作用に基づく保温効果は疲労回復,及び退行性変性の慢性疼痛緩解に適応を有する。生物に対する放射能は,すべて有害とする認識が一般的であるが,自然放射能を含めてその刺激作用によりbio-positiveの恩恵を受けている。ラドン泉浴によるbio-negativeの報告も見られる中で,ホメオスターシスの維持に必要なbio-positiveなhormetic effectsとしての刺激作用の解明が望まれる。
抄録(別表記) Radon bathings is indicated for chronic pain caused by degenerative changes in connective tissues by warming effect as a result of the improvement in tissue perfusion based on the experimental inhalation study for high concentration of Radon (13,764-23,743 Bq/ℓ). Radioactive radiation has been thought to be bio-negative in general. The environmental radiation in Misasa hospital of 80.7±7.8mBq/ℓ and 265.8±98.8mBq/ℓ in the steam bath room (727-2,395% of Rn-free district) may contribute on Rn spa therapy, as we have no experiences of bio-negative effects of Rn on epidemiology study. It seems probable that the early data of cosmic radiation effects to promote reproduction rate on the primitive organisms have significance and that the ambient radiation is essential for normal physiological function and life of the living organisms. In order to share the benefit of hormetic effects (hormesis) with Radon springs, optimal dosis should be determined together with the development of precise micro-dosimetry.
キーワード ラドン泉 (Radon springs) 適応症 (lndications) 放射能泉 (Radioactive springs) ホルミシス (Hormesis)
出版物タイトル 環境病態研報告
発行日 1989-07
60巻
開始ページ 72
終了ページ 75
ISSN 09133771
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/6511
言語 Japanese
論文のバージョン publisher
NAID 120005816789
JaLCDOI 10.18926/19813
タイトル(別表記) Absolute ethanol injection for non-parasitic hepatic cyst.
フルテキストURL 060_067_071.pdf
著者 森末 真八| 鈴鹿 伊智雄| 平井 俊一| 曽田 益弘| 得能 輝男| 古元 嘉昭| 砂川 満| 萬 秀憲| 小松原 正吉| 寺本 滋|
抄録 非寄生虫性肝嚢胞の3例に,超音波ガイド下にドレナージ及び純エタノール注入を行い,全例に嚢胞の著明な縮小効果を認めた。本法は手技も容易で,副作用も軽微であり,エタノール注入と嚢胞縮小効果の間には1カ月以上の時間的な経過を要するが,肝嚢胞に対して,外科的療法に代わる有用な治療法であると思われる。
抄録(別表記) Three patients suffering from nonparasitic hepatic cysts were successfully treated with absolute ethanol injection under ultrasonic guided puncture. As the procedure was simple and less invasive, it was considered that this treatment for hepatic cysts was an alternative to surgery. However, more than one month was needed, untill remqrkable shrinkage of cysts was expected in all three patients.
キーワード 肝嚢胞 (Liver cyst) 超音波ガイド下穿刺術 (Ethanol injection) エタノール注入療法 (Transcutaneous hepatic puncture)
出版物タイトル 環境病態研報告
発行日 1989-07
60巻
開始ページ 67
終了ページ 71
ISSN 09133771
言語 Japanese
論文のバージョン publisher
NAID 120002309013
JaLCDOI 10.18926/19790
タイトル(別表記) Oxygen inhalation therapy for chronic venous ulcer. -An additional treatment modality-
フルテキストURL 060_031_034.pdf
著者 古元 嘉昭| 得能 輝男| 曽田 益弘| 平井 俊一| 森末 真八| 鈴鹿 伊智雄| 砂川 満| 萬 秀憲|
抄録 長期にわたり反復する静脈性潰瘍は,静脈圧亢進により拡張した毛細管の増加とその周辺に滲出したフィブリンの沈着により,血液からの酸素,及び栄養物の供給が妨げられている。医用質量分析装置による皮下組織ガス分圧の評価で経鼻的に100 % の酸素吸入により潰瘍周辺への酸素供給が認められたので,重篤臨床例に対して静脈圧減圧処置に加えて酸素吸入を併用したところ,潰瘍の治癒傾向は著しく速くなり,補助療法としての意義を認めた。
抄録(別表記) Prolonged venous hypertension leads to increase the number of dilated capillaries and to fibrin deposition around them which may form a barrier to the diffusion of oxygen and other nutrients from the blood to the tissue, so that cell death and ulceration may occur. Following inhalation of 100 % -O(2), increased partial pressure of subcutaneous tissue oxygen (pO(2)) around the ulcer was confirmed by means of medical mass spectrometry, which was found comparable to or higher than the level of ulcer-free area (chest) on room air. Four patients suffering from chroriic ulcers were successfully treated by 100 % -O(2) inhalation, 4-5 ℓ/min, for one hour every day in addition to the simpie measures of reducing venous stasis. Suffice it to say that the inhalation of 100 % -O(2) may be applicative to an additional treatment modality in chronic venous ulceration, though inhalation of 100 % -O(2) for a long period of time may not be recommended.
キーワード 慢性静脈性潰瘍 (Chronic venous ulcer) 組織ガス分圧 (Partial pressure of tissue gases) 医用質量分析装置 (Medical mass spectrometer) 酸素拡散 (Oxygen diffusion) 酸素吸入療法 (Oxygen inhalation therapy)
出版物タイトル 環境病態研報告
発行日 1989-07
60巻
開始ページ 31
終了ページ 34
ISSN 09133771
言語 Japanese
論文のバージョン publisher
NAID 120002309180
JaLCDOI 10.18926/19767
タイトル(別表記) Changing conception of indication for peripheral arterial reconstruction surgery.
フルテキストURL 059_054_061.pdf
著者 古元 嘉昭| 中尾 俊彦| 砂川 満| 矢木 信子| 萬 秀憲|
抄録 末梢動脈の慢性閉塞性疾患に対する直達血行再建術の長期の予後は必ずしも満足できるものではない。合成代用血管は,長期の植え込みにより内被の肥厚,退行性変性,および材質の変性の様な合併症により,特に小口径の合成代用血管の適応は極めて限られたものになっている。一方,医用質量分析装置を用いた虚血肢の実験的研究によると,自由に運動させた犬の虚血肢では,急性期に比較すると3カ月以後その組織循環は有意に増加することが明らかとなった。また,家兎を用いた実験的研究によると,炭酸泉浴に高濃度のラドン吸入を合併すると皮下組織の組織循環が約30%増加して,同時に皮下の酸素分圧が上昇することを確かめた。従って,切迫壊死の症例をのぞいて,末梢動脈の慢性閉塞性疾患々肢,特に間欠性跛行に対しては,自 然予後を考慮して歩行負荷,および炭酸泉,ラドン泉の温泉療法を用いた保存的療法が長期の予後上効果的である。
抄録(別表記) Peripheral arterial reconstruction surgery for chronic occlusive diseases has not always produced satisfactory results according to long-term (5-10 years) follow-up studies. Furthermore, application of synthetic vascular prostheses of small caliber for peripheral reconstruction is quite restricted to certain circumstances, because of the complications derived from long-term implantation such as thickening and degeneration of the inner capsule and deterioration of the grafts used. On the other hand, experimental studies on ischemic limbs revealed a significant increase of tissue perfusion in 3, 6 and 12 months following ischemia was induced (p<0.001) compared with the acute ischemic stage in freely moving dogs by means of medical mass spectrometry. In addition, subcutaneous tissue perfusion was found increased by about 30 % with CO(2) bathings in combination with Radon inhalation of high concentration (over 5000 Bq/l), which was accompanied by an elevation of subcutaneous pO(2). Therefore, medical treatments such as walking exercise and bathings with CO(2) and Radon based on the natural history of chronic peripheral arterial occlusive diseases, particularly intermittent claudication, appear feasible.
キーワード 虚血肢 (lshemic limb) 末梢血行再建術 (Peripheral arterial reconstruction) 組織循環 (Tissue perfusion) 歩行運動 (Walking exercise) 温泉療法 (Balneotherapy)
出版物タイトル 環境病態研報告
発行日 1988-08
59巻
開始ページ 54
終了ページ 61
ISSN 09133771
言語 Japanese
論文のバージョン publisher
NAID 120002309045
JaLCDOI 10.18926/19727
タイトル(別表記) Clinical effects of serial artificial CO(2) baths on degenerative disorders in consideration of the improved tissue perfusion.
フルテキストURL 058_022_030.pdf
著者 古元 嘉昭| 河本 知二| 砂川 満| 矢木 信子| 萬 秀憲| 松本 泰伸|
抄録 組織循環の良不良は,結合織の退行性病変の予後に大いに影響をおよぼすものである。人工炭酸泉を用いた実験的検討で,すでに組織循環の30 % 増加を認めており,臨床的治験により好傾向を示す結果を得つつある。結合織病変を主とする慢性疾患4症例の治験前後に局所組織流量を測定して評価することができた。局所組織流量は医用質量分析装置を介したオンラインシステムで測定計算した。人工炭酸浴は,炭酸ガスキャビン,および人工炭酸浴剤浴を用いた。人工炭酸泉浴は,1カ月より1年におよび,それぞれ自覚症状の著名な改善と,組織流量の増加を定量しえた。人工炭酸泉の連浴による組織流量の改善は、結合織の退行性病変に有効に作用するものである。
抄録(別表記) Tissue perfusion plays an important role in prognosis of the deteriorating connective tissue disorders. Tissue perfusion was evaluated before and after CO(2) treatment on the patients with connective tissue disorders by means of medical mass spectrometer. CO(2) treatment was performed in 2 ways ; one was with CO(2)-cabine, 20 litres per minute at 40℃ for 20 minutes, and the other was with an artificial CO(2) bathing prepared with 2 tablets of BUB-KAO, a 50 g sodium hydrogencarbonate and succinic acid tablet, in 280-litre-tub at 40℃ for 20 minutes. Case 1, 33-year-old female, suffering from chronic rheumatic arthritis with rheumatic thromboangiitis obliterans in the left 5th toe. Main arterial trees were found intact arteriographically. Her joint pain and muscle stiffness have been improved markedly after CO(2) treatment with cabin every day for one month though every medicine for rheumatism made little effect. Case 2, 46-year-old female, suffered from progressive systemic scleroderma. Major blood supply was found not blocked in upper extremities arteriographically. Tissue perfusion was found poor in muscle tissue of each forearm before CO(2) treatment with cabin, whereas an improved tissue perfusion was confirmed after one month of serial CO(2) treatment, leading to ameliorate persistent muscle stiffness, though every medicine for her made slow effect. Case 3, 48-year-old female, suffering from the weakness in strength with no positive laboratory findings of connective tissue disorders. Tissue perfusion has been found quite improved following serial artificial CO(2) bathings for 12 months, being able to work hard every day as a nurse. Serial CO(2) bathing is thought to be very useful in ameliorating the symptoms of deteriorating connective disorders by virtue of an improved tissue perfusion.
出版物タイトル 環境病態研報告
発行日 1987-08
58巻
開始ページ 22
終了ページ 30
ISSN 09133771
言語 Japanese
論文のバージョン publisher
NAID 120002309112
JaLCDOI 10.18926/19651
タイトル(別表記) Clinical trials with artificial CO(2) bathings
フルテキストURL 057_012_017.pdf
著者 薄井 泰子| 古元 順子| 砂川 満| 河本 知二| 古元 嘉昭|
抄録 パブ浴(人工炭酸浴剤浴)は,組織に酸素を供給し,また組織循環の改善により組織に賦活力を与え,さらに末梢毛細血管の拡張作用を有する。外来患者を対象に,末梢循環障害5例,高血圧症2例,不定愁訴症例2例を選び,半年より1年にわたって家庭でパブ浴を連浴させた。全例に,併用薬の減量,あるいは中止をみた。とくに蛋白尿を伴った高血圧症例では,血圧の正常化に伴って蛋白尿の減少をみた。炭酸泉の効果は連浴によっても変化を認めず,人工炭酸泉浴は家庭においても療養泉としての効果がえられ,疾病の自然予後に有為に作用する。
抄録(別表記) Clinical trials for 5 cases of peripheral circulation insufficiency, 2 cases of hypertension, 2 cases of general malaise and 2 cases of liver function insufficiency were performed with artificial CO(2) baths using BUB-KAO, a 50 g sodium hydogencarbonate and succinic acid tablet, KAO Co. Ltd., Japan, in 150-litre-tub at 40℃ for 10-20 minutes in a period of 6 to 12 months. By virtue of an increase of tissue PO(2) and an improvement of tissue perfusion with artificial CO(2) baths, favorable effects were obtained in all cases but in 2 patients with liver function insufficiency, leading to reduce or discontinue the regular medications. Remarkable effect was observed in 2 cases of hypertension, being brought under control in 2 months, keeping normal range thereafter due possibly to lowering the peripheral resistance caused by capillary dilation effect. A greate favor of hypotensive effect was granted in reducing the excretion of urinary protein. It is very advantageous in maintaining homeostasis to ameliorate natural course of diseases with artificial C (2) baths which are effective by repeated routine use for a long period of time, leading to assist modern way of medical treatment.
キーワード 人工炭酸泉浴 (Artificial CO(2) bath) 連浴 (serial bathing) 末梢循環障害 (peripheral circulation insufficiency) 高血圧症 (hypertension) 不定愁訴 (general malaise)
出版物タイトル 環境病態研報告
発行日 1986-07
57巻
開始ページ 12
終了ページ 17
ISSN 09133771
言語 Japanese
論文のバージョン publisher
NAID 120002309069
JaLCDOI 10.18926/19647
タイトル(別表記) Screening test for chromosome aberrations of long-time residents in misasa spa.
フルテキストURL 057_009_011.pdf
著者 古元 嘉昭| 河本 知二| 砂川 満| 矢木 信子| 御船 政明|
抄録 三朝温泉のラドン含有は,源泉で約1347~2694Bq/l,常用温泉水で137~224Bq/l,また,屋内では7.3~73.7Bq/lである。三朝温泉地に出生して,28~75年にわたる入浴者9名,および三朝温泉地外に出生して16~78 年にわたる入浴者4名について末梢静脈血の染色体検査を,ギムザ染色,および特に長年入浴している3名についてはG一分染法による分析を行なった。浴水,および生活環境のラドン濃度の多寡によらず,長年の入浴によっても染色体の構造変化は正常範囲内であった。
抄録(別表記) Screening test for chromosome aberrations of 13 long time residents, 9 native and 4 movingin in Misasa Spa was performed. Each Radon content in baths ranges 166-224 Bq/l, in homes 8.6-73.7 Bq/l, and in offices 8.4-22 Bq/l. Normal Karyotypes on both sexes and normal range of aberrations, gaps and breaks, were found in chromosome analyses. There are no significant radioactive effects from longtime bathings and from environment in both groups of Misasa spa districts, corresponding to the facts of no significant incidence of infertility, malformations, a brief span of life, and neoplasms compared to other places.
キーワード 三朝温泉地 (Misasa spa) ラドン泉 (Radon bath) 染色体異常 (Chromosome aberration)
出版物タイトル 環境病態研報告
発行日 1986-07
57巻
開始ページ 9
終了ページ 11
ISSN 09133771
言語 Japanese
論文のバージョン publisher
NAID 120002309001
JaLCDOI 10.18926/11695
タイトル(別表記) Antithrombogenic therapy after heart valve replacement - Effect of anti-platelet drug on aggregation-
フルテキストURL 061_055_060.pdf
著者 曽田 益弘| 萬 秀憲| 鈴鹿 伊智雄| 森末 真八| 平井 俊一| 古元 嘉昭| 梶谷 伸顕| 吉實 憲| 浪花 宏幸| 古城 昌義| 寺本 滋|
抄録 人工弁置換患者の血栓塞栓症(TE)は,長期予後の成績を左右する。 TEを減少させるために凝固因子を抑制するwarfarinと抗血小板剤による抗血栓療法が行われている。人工弁置換患者103例を対象に,抗血小板剤であるtrapidil(TP)とdipyridamole(DP)の血小板凝集能に与える効果を検討した。36ヵ月間検討したが,warfarin単独群は血小板凝集能に変化がなく,TP,DP共にADP凝集能を抑制した。しかし有意差の見られたのは全経過ではなく,凝集能抑制は強力かつ持続的ではなかった。またコラーゲン誘導凝集能は変化を認めなかった。TPとDPの抗血小板効果は同等と思われる。期間中の血栓塞栓発生は,warfarin単独群9.5%,TP群4.3%,DP群7.7%であった。臨床的に抗血小板剤の併用は有効と思われるが,血小板凝集抑制には投与量の増量,あるいは他の薬剤の検討が必要であろう。
抄録(別表記) To evaluate the effect of anti-thrombotic thrapy after valve replacement, serial platelet aggregation measurememnts were carried out in 103 patients. Patients were divided into three groups. e. i. warfarin alone (control), warfarin with trapidil (TP) of 300mg/day and dipyridamole (DP) of 300mg/day. The aggregation of platelet of the control group did not change through 36 months. TP group showed a decrease in platelet aggregation at 24 and 30 months from the pretreatment value. The aggregation of 24 month in TP was significantly lower than that of control. There was no difference of platelet aggregation between TP and DP group. The incidence of thromboembolism of control, TP and DP group were 9.5%, 4.3% and 7.7%, respectively. These data suggest that the supression of platelet aggregation .by TP and DP is not adequate to continue for long time and TP has similar anti-thrombotic effect to DP.
キーワード 人工弁置換術 (Heart valve replacement) 血栓塞栓症 (Thromboembolism) 血小板凝集 (Platelet aggregation) 抗血小板剤 (Anti-thrombotic drug)
出版物タイトル 環境病態研報告
発行日 1990-09
61巻
開始ページ 55
終了ページ 60
ISSN 0913-3771
言語 Japanese
論文のバージョン publisher
NAID 120002313443
JaLCDOI 10.18926/11685
タイトル(別表記) 日本に於ける二酸化炭素泉療法の現況
フルテキストURL 061_068_072.pdf
著者 古元 嘉昭| 曽田 益弘| 平井 俊一| 森末 真八| 鈴鹿 伊智雄| 萬 秀憲|
抄録 Natural CO(2) springs have been scarcely utilized in Japan, whereas artificial CO(2) bathing has become popular by the introduction of CO(2) tablets and other apparatus for CO(2) water supply. Artificial CO(2) bathing is indicated for degenerative connective tissue disorders such as scleroderma, common stiff and painful shoulders, chronic joint pain, lumbago, and trophic changes due to insufficient peripheral circulation by virtue of the increase of tissue pO(2) and the improvement of tissue perfusion. Artificial CO(2) bathing promotes recovery from fatigue and is beneficial in women whose health has been adversely affected by cold.
抄録(別表記) 日本では,天然の二酸化炭素泉は殆ど利用されていない。一方,CO(2)錠剤,CO(2)給水装置が開発されて人工二酸化炭素泉がよく用いられるようになってきた。皮下組織の酸素分圧の上昇と組織循環の改善という好ましい生理作用により,結合織の退行性変化による慢性障害,すなわち強皮症,関節症,慢性関節痛,腰痛症,および末梢循環障害に伴う組織の栄養障害に適応がある。また,疲労回復を促進し,いわゆる冷え症に好ましく作用する。
キーワード CO(2) -balneotherapy Artificial CO(2) -bathing Tissue pO(2)
出版物タイトル 環境病態研報告
発行日 1990-09
61巻
開始ページ 68
終了ページ 72
ISSN 0913-3771
言語 English
論文のバージョン publisher
NAID 120002313982
JaLCDOI 10.18926/11679
タイトル(別表記) Clinical evaluation of new formula included oligopetide as a nitrogen source in surgical patients
著者 曽田 益弘| 萬 秀憲| 森末 真八| 平井 俊一| 鈴鹿 伊智雄| 古元 嘉昭| 梶谷 伸顕| 吉實 憲| 浪花 宏幸| 寺本 滋|
抄録 窒素源としてdi-,tri-peptideを含有した経腸栄養剤を外科患者に使用した。.この新しい経腸栄養剤は卵白を加水分解したもので,70%がoligopeptideであり,アミノ酸も10%含まれる。糖質はデキストリンで,脂肪の含有量は少なく浸透圧はエレメンタルダイエット(ED)より低い。この製剤を安定期および術後に使用した。アルブミン,rapid turnover proteinの回復がみられ,臓器蛋白の合成が得られた。術後例では3メチルヒスチジンの排泄量は減少せず,異化反応は抑制されなかった。投与量の不足が一つの原因と思われる。副作用の下痢はほとんどみられず,栄養改善効果もあり,有用性が認められた。
抄録(別表記) The clinical usefulness of new enteral formula which is contained di-and tri-peptides as a nitrogen source was evaluated in surgical patients. The enteral nutrition was introduced to stable patients who could not take food orally and postoperative ones who were undertaken upper GI surgery. Adverse effects such as diarrhea or abdomonal distension were not observed. V isceral proteins were improved after administration of this regimen and nutritional status was maintained in all patients. However, high urinary excretion of 3methylhistidine continued in great extent during postopertive period and breakdown of skeletal muscle was not prevented by this nutritional therapy. This might be due to insufficient intake of energy and nitrogen. This new product for enteral nutrition would be safe and useful as enteral nutrition.
キーワード 経腸栄養 (Enteral nutrition) エレメンタルダイエット (Elemental diet) オリゴペプチド (Oligopeptide) 外科栄養 (Surgical nutrition)
出版物タイトル 環境病態研報告
発行日 1990-09
61巻
開始ページ 61
終了ページ 67
ISSN 0913-3771
言語 Japanese
論文のバージョン publisher