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ID 16636
Eprint ID
16636
フルテキストURL
Thumnail 94_1.pdf 1.38 MB
タイトル(別表記)
Antinuclear antibodies in patients with scleroderma.
著者
古田 嘉男 岡山大学医学部第三内科学教室
抄録
Antinuclear antibodies were detected in 30 of 38 (79%) patients with scleroderma by indirect immunofluorescence using rat liver sections as a substrate. Seventeen of 30 patients who were positive for antinuclear antibodies also had antinucleolar antibodies.Antibodies to non-histone nuclear antigens were identified by double immunodiffusion in 0.45% agarose. The incidence of anti RNP antibody was 13%; anti SS-A antibody, 45%; anti SS-B antibody, 13%; anti Sm antibody, 0%; anti MU antibody, 0%; anti Scl-l antibody, 58%.Scl-1 antigen was not found in isotonic saline soluble extracts of human spleen, human liver, rabbit thymus, rat liver or Raji cell. Alternatively, the antigen was extracted from these organs with hypertonic salt solutions (0.3M, 0.6M, 1.0M, NaCl). The antigen was inactivated by heating at 37•Ž for 1 hour. It was resistant to digestion with deoxyribonuclease or ribonuclease, and was destroyed by trypsin digestion.Antibodies to Scl-1 antigen were detected in sera from 22 of 38 (58%) patients with scleroderma, 1 of 10 (10%) with sclerodermatomyositis, 1 of 26 (4%) with mixed connective tissue disease and 1 of 32 (3%) with undifferentiated connective tissue disease having anti RNP antibody. Anti Scl-1 antibody was not present in sera from 18 patients with polymyositis or dermatomyositis, 88 with systemic lupus erythematosus, 55 with rheumatoid arthritis, 44 with sicca complex or 24 with Hashimoto's thyroiditis. The patients with scleroderma had a significantly high incidence of the antibody (P<0.01). The present study suggests that anti Scl-1 antibody might be a useful marker for scleroderma.
キーワード
強皮症
抗核抗体
非ヒストン核
蛋白抗体
抗Scl-1抗体
発行日
1982-02-28
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
94巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1
終了ページ
8
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/94/1-2/94_1-2_1/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma