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ID 13960
Eprint ID
13960
フルテキストURL
Thumnail 106_187.pdf 649 KB
タイトル(別表記)
Studies on the effect of chemotherapy for multiple myeloma with analysis of bone lesion Part 1. Combination chemotherapy effect for multiple myeloma with aclarubicin, vincristine, cyclophoshamide and prednisolone including analysis on prognostic factors
著者
和泉 健 岡山大学医学部第二内科学教室
抄録
Sixty-one patients with multiple myeloma consisting of 45 previously untreated and 16 previously treated patinets were given combination therapy of aclarubicin, vincristine, cydlo-phosphmide and prednisolone. The overall response rate evaluated by 50% reduction in M-protein was 47%. The median survival time 40 months, which indicated satisfactory effectiveness. The previously untreated patients with stage Ⅲ disease had a much higher response rate (58%) than those with stage Ⅱ (33%). There was no significant difference in the 5-year survival between the patients with stage Ⅲ (33%) and stage Ⅱ (33%) disease. These findings indicate the effectiveness of the therapy for stage Ⅲ cases, especially patients with stage Ⅲ disease under good control showed long-term survival of more than 5 years. Marked symptomatic inpovement was observed in 77%. For patients with advanced bone lesion the therapy was also valuable. The multivariate anaysis (proportional hazard model of Cox) of individual biochemical and clinical variables showed that the tumor was the most significant variable related to prognos-tic factor followed by good and poor control and serum calcium level. Hematologic toxicity, infection, nausea and vomiting occurred frequently, although the incidence of ECG change (9%) was low and transient.
キーワード
multiple myeloma
combination chemotherapy
prognostic factor
multivariative analysis
bone status
備考
原著
発行日
1994
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
106巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
187
終了ページ
198
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/106/3-4/106_3-4_187/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma