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タイトル(別表記) Giant rectal gastrointestinal stromal tumor successfully resected by abdominoperineal resection combined with posterior vaginal wall resection
フルテキストURL 126_217.pdf
著者 岩川 和秀| 西江 学| 徳永 尚之| 宮宗 秀明| 岩垣 博巳|
抄録 We report a case of giant rectal gastrointestinal stromal tumor (GIST) successfully resected by abdominoperineal resection combined with posterior vaginal wall resection. Our patient was a 79-year-old woman had been diagnosed as having von Recklinghausen disease at the age of 30 years. In 2006, a computed tomography (CT) scan revealed a tumor originating from the posterior wall of the rectum. In June 2010, she was admitted to our hospital with the chief complaint of bloody stool. A CT scan revealed a giant tumor that had increased to 9cm in size. Colonoscopy demonstrated a submucosal tumor, which was subsequently diagnosed by biopsy as a GIST. Due to the patient's continuous bleeding and abdominal pain, an emergent abdominoperineal resection was performed at that time. The tumor, which measured 8×9cm, was immunohistochemically positive for c-kit and CD34. Concomitant resection of the posterior wall of the vagina via the perineal approach provided a wide area to expose the tumor for a safe operation. The patient has been well with no sign of recurrence since the operation. This procedure is recommended as a useful approach for giant rectal GISTs or rectal cancer with invasion of the posterior pelvic wall.
キーワード 巨大直腸GIST(giant rectal GIST) 腹会陰式直腸切断術(abdominoperineal resection)
備考 症例報告 (Case Reports)
出版物タイトル 岡山医学会雑誌
発行日 2014-12-01
出版者 岡山医学会
出版者(別表記) Okayama Medical Association
開始ページ 217
終了ページ 221
ISSN 0030-1558
NCID AN00032489
資料タイプ 学術雑誌論文
言語 Japanese
著作権者 Copyright (c) 2014 岡山医学会
論文のバージョン publisher
査読 有り
DOI 10.4044/joma.126.217
NAID 130004903245
Eprints Journal Name joma
参考文献 1) Miettinen M, Lasota J : Gastrointestinal stromal tumors (GISTs) : definition, occurrence, pathology, differential diagnosis and molecular genetics. Pol J Pathol (2003) 54, 3-24. 2) 小西 毅, 渡邉聡明, 名川弘一 : 直腸gastrointestinal stromal tumor (GIST)の臨床的特徴. 日外科系連会誌 (2004) 29, 169-173. 3) Hirota S, Isozaki K, Moriyama Y, Hashimoto K : Gain of function mutations of c-kit in human gastrointestinal stromal tumors. Science (1998) 279, 577-580. 4) Maertens O, Prenen H, Rychter MD, Wozniak A, Sciot R, Pauwels P, Wever I, Vermeesch JR, Raedt T, Paepe A, Speleman F, Oosterom A, et al. : Molecular pathogenesis of multiple gastrointestinal stromal tumors in NF1 patients. Hum Mol Genet (2006) 15, 1015-1023. 5) 王 孔志, 中井紀博, 岡田敏弘, 飯室勇二, 廣田誠一, 藤本治朗 : メシル酸イマチニブによる術前補助療法が奏効した巨大直腸GISTの1例. 日臨外会誌(2010)71, 1806-1811. 6) 山下和城, 久保添忠彦, 山村真弘, 松本英男, 浦上 淳, 平井敏弘, 角田 司 : Imatinib mesylateによるneoadjuvant therapyが有効であった巨大直腸GISTの1例. 日本大腸肛門病会誌(2006)59, 24-30. 7) Kusumoto Y, Soda K, Shuto Y, Konishi F : A case of gastrointestinal stromal tumor of the rectum resected by the transvaginal approach. Jichi Medical School Journal (2004) 27, 145-154. 8) 尾形 徹, 川本 純, 山東敬弘, 藤本三喜夫, 中井志郎, 増田哲彦, 安井 弥 : 直腸膣中隔に発症したgastrointestinal stromal tumor (uncommitted type) の1例. 日臨外会誌(2001)62, 988-991.
著者 宮宗 秀明| 西江 学| 岩垣 博巳| 石井 裕朗| 藤田 勲生| 友田 純|
発行日 2010-08-02
出版物タイトル 岡山医学会雑誌
資料タイプ 学術雑誌論文