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ID 15955
Eprint ID
15955
フルテキストURL
Thumnail 100_565.pdf 4.14 MB
タイトル(別表記)
Studies on the role of cell mediated immunity in the pathogenesis of intractable asthma -Evaluation of interleukin 2 production in response to Candida antigen-
著者
宮川 秀文 岡山大学医学部第二内科学教室
抄録
Candida antigen is known to be the major causative agent of adult bronchial asthma, especially intractable asthma. High responsiveness of lymphocytes in bronchoalveolar lavage fluid (BALF) to Candida antigen has been reported in patients with intractable asthma. Therefore, IL-2 production of peripheral blood (PB) lymphocytes and BALF lymphocytes in patients with various types of bronchial asthma was evaluated to clarify the role of cellular immunity against Candida antigen in the pathogenesis of intractable asthma. IL-2 production of PB lymphocytes in intractable asthma patients was higher than in non-intractable asthma patients and normal controls (p<0.01). Patients with intractable asthma receiving prednisolone at a dose of over 10mg/day showed lower IL-2 production by PB lymphocytes than patients receiving prednisolone at a dose of under 10mg/day. The direct suppressive effect of prednisolone was also evaluated in a vitro study, which revealed that the suppression of IL-2 production was dose dependent in the range of therapeutic concentrations. IL-2 production by BALF lymphocytes against Candida antigen was also studied, and it was shown that IL-2 production was higher in intractable asthma patients than in non-intractable asthma patients (p<0.01). IL-2 production correlated significantly (p<0.05) with lymphocyte blastogenic responses against Candida antigen in patients with intractable asthma.
キーワード
intractable asthma
Candida antigen
interleukin 2 production
発行日
1988
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
100巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
565
終了ページ
575
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/100/5-6/100_5-6_565/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
OAI-PMH Set
岡山大学
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Sort Key
49
Eprints Journal Name
joma