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ID 15957
Eprint ID
15957
フルテキストURL
Thumnail 100_577.pdf 2.29 MB
タイトル(別表記)
Studies on the role of cell mediated immunity in the pathogenesis of intractable asthma -Evaluation of neutrophil chemotactic activity induced by Candida antigen-
著者
宮川 秀文 岡山大学医学部第二内科学教室
抄録
The role of cellular immunity in the pathogenesis of intractable asthma was studied. Increased IL-2 production in intractable asthma patients as the result of lymphocyte response to Candida antigen was shown in the previous paper. Although the exact role of cellular immunity in the pathogenesis of intractable asthma is still obscure, various activities of lymphokines are suspected of contributing to intractable asthma. While neutrophils are well known to release various chemical mediators, neutrophils in bronchoalveolar lavage fluid (BALF) has been reported to increase in patients with intractable asthma. The accumulation of neutrophils could be important in the pathogenesis of intractable asthma. Therefore, neutrophil chemotactic activity (NCA) derived from mononuclear cell culture with Candida antigen was studied. High NCA was observed in patients with intractable asthma in comparison with patients with non-intractable asthma and normal controls. Intractable asthma patients raceiving prednisolone at a done of over 10mg/day showed less NCA than patients receiving prednisolone at a dose of under 10mg/day. NCA levels in the culture supernatant correlated with IL-2 levels in the same culture supernatant. It seemed likely that NCA is derived at least in part, from the lymphocyte blastogenic response to Candida antigen.
キーワード
intractable asthma
Candida antigen
neutrophil chemotactic activity
発行日
1988
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
100巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
577
終了ページ
587
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/100/5-6/100_5-6_577/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma