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ID 16291
Eprint ID
16291
フルテキストURL
Thumnail 95_347.pdf 936 KB
タイトル(別表記)
CSF monoamine metabolites and cyclic nucleotides in depression
著者
宮内 和瑞子 岡山大学医学部神経精神医学教室
抄録
Monoamine metabolites (5HIAA, HVA and MHPG) and cyclic nucleotides (c-AMP and c-GMP) were determined in lumbar CSF from 16 healthy controls and 36 patients hospitalized for depression. Determination of monoamine metabolites in the depressed patients was performed before and after treatment with antidepressants. The diagnosis was made according to the DSM-III (1980). The following results were obtained: 1) 5HIAA in patients with major depression was significantly lower than in controls regardless of the severity of clinical symptoms, while it was unchanged in patients with the bipolar affective disorder. It is suggested that major depression may differ biologically from the bipolar disorder. 2) The low CSF-5HIAA values in patients with major depression may not be dependent on the clinical state, but rather on a genetic trait, because they were not changed by clinical improvement or treatment with antidepressants. 3) As the initially low CSF-HVA levels in the depressed patients increased along with clinical improvement of the affective retardation, low CSF-HVA levels seem to be clinical state dependent rather than trait dependent in such patients. 4) CSF-MHPG was unchanged in the untreated depressed patients, while it decreased significantly after treatment with any of antidepressants. 5) After treatment both CSF c-AMP and c-GMP levels in completely recovered patients were significantly higher than those in control and un-improved patients. As an increase in c-AMP was found to be related to clinical improvement of depression, it seems to be state dependent in the depressed patients.
キーワード
うつ病
髄液
DSM-III
アミン代謝物質
環状ヌクレオチド
発行日
1983-04-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
95巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
347
終了ページ
367
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/95/3-4/95_3-4_347/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma