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ID 16277
Eprint ID
16277
フルテキストURL
Thumnail 95_253.pdf 461 KB
タイトル(別表記)
Studies on peripheral monocytes in diabetes mellitus. Part I. Monocyte chemotaxis in diabetes mellitus.
著者
宮原 潔 岡山大学医学部第2内科教室
抄録
Chemotaxis of diabetic monocytes was studied. The use of 0.25 x 10(6) monocytes, 20% Zymosan activated serum and incubation at 37℃ for 90 minutes were found to be the optimal assay conditions for the Boyden chamber method using a nuclepore filter. Under these conditions, monocyte chemotaxis was tested in 48 diabetics and 27 normal controls. The results were as follows: 1) Diabetics had low monocyte chemotaxis, especially in aged patients. The normal controls showed no difference with aging. 2) Poorly controlled diabetics showed significantly lower chemotaxis than both normal controls(P<0.005) and good controlled diabetics(P<0.05). The mean values were 40.1±32.4, 71.3±29.9 and 61.4±36.2 monocytes/HPF, respectively. 3) There was no difference in monocyte chemotaxis between diabetic groups treated with diet alone, oral agents or insulin. 4) Six of nine poorly controlled diabetics showed increased monocyte chemotaxis after being good controlled with insulin.
キーワード
糖尿病 (diabetes mellitus)
単球 (monocyte)
走性 (chemotaxis)
発行日
1983-04-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
95巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
253
終了ページ
262
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/95/3-4/95_3-4_253/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma