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ID 15967
Eprint ID
15967
フルテキストURL
Thumnail 99_863.pdf 786 KB
タイトル(別表記)
Effects of copper, cadmium, zinc and two mixtures of these metals on oxidative phosphorylation, ATPase and electron transport of isolated rat liver mitochondoria.
著者
宮地 芳之 岡山大学医学部公衆衛生学教室
抄録
The effects of metals on oxdative phosphorylation, ATPase and electron transport were examined. Cadmium accelerated state 4 respiration and increased latent ATPase activity, indicating that cadmium is an uncoupler of the energy transport reaction. Cadmium did not inhibit site 1, 2 or 3 of the electron transport chain. Copper inhibited state 3 respiration, accelerated state 4 respiration, increased latent ATPase activity and decreased stimulated ATPase activity, indicating that copper is an uncoupler and effects the energy tranport reaction. Copper did not inhibit site 1, 2 or 3 of the electron transport chain. Zinc inhibited state 3 and state 4 respiration, increased latent ATPase activity, decreased stimulated ATPase activity slightly, and inhibited sites 1 and 2 of the electron tranport chain. One pair of the 3 metals had additive effects on state 3 and 4 respiratory activity and on stimulated and latent ATPase activity. A competitive reaction between copper and zinc was observed in the effects on sites 1 and 2 of the electron transport chain.
キーワード
Mitochondria
Cadmium
Copper
Zinc
Oxidative phosphorylation
ATPase
Electron Transport System
発行日
1987-08-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
99巻
7-8号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
863
終了ページ
879
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/99/7-8/99_7-8_863/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma