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ID 17091
Eprint ID
17091
フルテキストURL
Thumnail 89_299.pdf 3.09 MB
タイトル(別表記)
Enzymological studies in rheumatoid arthritis Part 1: Studies on the lysosomal enzyme activities in rheumatic diseases
著者
寺見 武人 岡山大学医学部大藤内科教室
抄録
Lysosomal enzymes were examined in synovial fluid, synovium, synovial fluid leukocytes and peripheral blood leukocytes of 40 rheumatoid arthritis (RA) patients and in synovial fluid and synovium of 19 osteoarthritis (OA) patients. Complement level and anticomplementary activity were examined in 13 RA synovial fluid. The results are summarized as follows: 1, In the supernatant synovial fluid and the synovium of RA patients, cathepsin D (C-D) and β-glucuronidase (β-G) activities were higher than those of OA patients. A positive correlation was present between the synovial fluid leukocyte count and C-D activity and between synovial fluid leukocyte count and β-G activity. RA synovial localization of β-G activity was demonstrated by light microscopy. The synovial lining cell of RA patients showed the strongest β-G localization. 2, No significant differences were found in C-D and β-G activities between RA synovial fluid leukocytes, RA peripheral blood leukocytes and normal human peripheral blood leukocytes. These results suggested that there were little differences in the inflammatory leukocytes and the noninflamatory leukocytes. 3, C-D and β-G activities in the supernatant synovial fluid and synovial fluid leukocytes were higher in RA patients with positive RF in synovial fluid than negative RF in synovial fluid. The results of this study suggested that the RF was displaced to the inflamation RA joint. 4, The presence of low complement levels and anticomplementary activity in RA synovial fluid suggested the role of the immune complex in the RA synovial cavity. 5, These results suggest that the high level of lysosomal enzymes in RA synovial fluid was due chiefly to the synovial membrane.
発行日
1977-04-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
89巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
299
終了ページ
308
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/89/3-4/89_3-4_299/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma