フルテキストURL JRNC_313_1_169.pdf
著者 Kudo, Ken-ichi| Hanafusa, Tadashi| Ono, Toshiro|
キーワード Monoterpenes Linalool X-ray irradiation Reactive oxygen species SSB
備考 The final publication is available at Springer
発行日 2017-07
出版物タイトル Journal of Radioanalytical and Nuclear Chemistry
313巻
1号
出版者 Springer
開始ページ 169
終了ページ 174
ISSN 0236-5731
NCID AA11120189
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
関連URL https://doi.org/10.1007/s10967-017-5268-0
JaLCDOI 10.18926/AMO/55204
フルテキストURL 71_3_219.pdf
著者 Takakura, Hiroaki| Domae, Shohei| Ono, Toshiro| Sasaki, Akira|
抄録  Anticancer drugs induce cell-cycle arrest and apoptosis not only in tumor cells, but also in immune cells. However, many preclinical and clinical findings show that some chemotherapeutic agents can improve the antitumor efficacy of immunotherapy. We immunohistochemically analyzed the degree of immune cell infiltration and the relevance of programmed cell death 1 ligand-1 (PD-L1) expression in surgically resected oral squamous cell carcinoma (OSCC) specimens from patients who had undergone pretreatment with certain chemotherapies and other patients without pretreatment. We divided the patients into the group of neoadjuvant chemotherapy (NAC) patients (n=8) and the nNAC (without NAC) patient group (n=10). We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment. Decreased numbers of Tregs and PD-1-positive cells were observed in the NAC group. No significant difference was observed in the degree of immune-cell infiltration between the patient groups except for CD56 NK cells in the stroma and PD-1 cells in cancer nests. Eighty percent of the nNAC specimens showed intermediate-to-strong PD-L1 protein expression, whereas 75% of the NAC specimens showed down-regulation of the PD-L1 protein, indicating the effectiveness of the chemotherapeutic treatment before surgery.
キーワード oral squamous cell carcinoma programmed cell death 1 ligand-1 tumor microenvironment neoadjuvant chemotherapy immunohistochemistry
Amo Type Original Article
発行日 2017-06
出版物タイトル Acta Medica Okayama
71巻
3号
出版者 Okayama University Medical School
開始ページ 219
終了ページ 226
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 28655941
著者 Nishiyama, Yuichi| Hanafusa, Tadashi| Yamashita, Jun| Yamamoto, Yoko| Ono, Toshiro|
発行日 2015-06-20
出版物タイトル Journal of Radioanalytical and Nuclear Chemistry
資料タイプ 学術雑誌論文
著者 Hanafusa, Tadashi| Mohamed, Ali Eldib Ali| Kitaoka, Kenta| Ohue, Yoshihiro| Nakayama, Eiichi| Ono, Toshiro|
発行日 2011-02-01
出版物タイトル Cancer Letters
301巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/45267
フルテキストURL 65_2_91.pdf
著者 Nagamatsu, Tomohiro| Sakoda, Akihiro| Kataoka, Takahiro| Ono, Toshiro| Yamaoka, Kiyonori|
抄録 No research has been conducted on the radiation influence of tobacco on the alimentary system, although there have been some previous works on the respiratory system. In this study, the radioactive concentrations of 210Pb and 40K in a cigarette sample were first measured. The transfer factors of the nuclides from tobacco into smoke and solution (saliva and/or alcohol) were then examined. Moreover, the radiation doses from smoke inhalation were also evaluated. The radioactive concentrations of 210Pb and 40K in the cigarette tobacco were 0.01 and 0.3 Bq/cigarette. Since this 210Pb activity and the 210Po activity previously reported for the same sample were comparable, it can be concluded that there was a radioactive equilibrium between the 2 nuclides. The observed transfer factor of 210Pb (12%) into smoke was almost the same as that of 40K (15%), whereas the reported value for 210Po (60%) was significantly higher. The radiation doses due to inhalation of cigarette smoke varied from organ to organ, depending on the organotropic properties of the nuclide. For example, the kidneys, respiratory tract, and spleen showed relatively high doses from 210Pb and 210Po. The leaching rates indicated an inconsistent tendency related to solution types. This result could suggest that alcohol drinking, which is common in smokers, does not especially enhance the leaching characteristics.
キーワード tobacco radionuclides smoking intake radiation exposure
Amo Type Original Article
発行日 2011-04
出版物タイトル Acta Medica Okayama
65巻
2号
出版者 Okayama University Medical School
開始ページ 91
終了ページ 95
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 21519366
Web of Sience KeyUT 000289818800004
JaLCDOI 10.18926/AMO/31119
フルテキストURL fulltext.pdf
著者 Nishioka, Keiko| Saito, Chisato| Nagano, Toshiaki| Okano, Mitsuhiro| Nakagawa, Fumio| Nishioka, Satoko| Masuda, Yu| Ono, Toshiro|
抄録 <p>To determine the allergens of mite allergic rhinitis, we studied 31 patients with mite allergic rhinitis by skin tests and nasal provocation tests (15 for skin and 16 for nasal tests) using 6 fractions of Dermatophagoides pteronyssinus (Dp) extract differing in molecular weights (15, 25, 32, 53, 95 and 190 kDMW). In skin testing, patients showed intense positive reactions to the fractions of 15, 25, 32, 95 and 190 kDMW, among which the most patients showed positive reactions to the fractions of 15 and 25 kDMW. Significant differences were found in patients' positive reactivity among each fraction and between low (15 and 25 kD) and high (95 and 190 kD) molecular weight fractions as well. In nasal provocation tests, patients showed intense positive reactions to the fractions of 15, 32, 53 and 95 kDMW, especially to the fractions of 15 and 95 kDMW. Furthermore, the insidence of positive reactions to the 15 kDMW fraction was significantly higher than that to any other fraction in the skin tests (P &#60; 0.05). From these results, the low molecular weight fraction, 15 kDMW, is considered to be the main allergen of this mite and the high molecular weight fractions, 95 and 190 kDMW, may also be considered to be allergens of this mite.</p>
キーワード mite allergen skin test nasal provoration test allergen rhinitis
Amo Type Article
発行日 1994-10
出版物タイトル Acta Medica Okayama
48巻
5号
出版者 Okayama University Medical School
開始ページ 279
終了ページ 282
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 7863799
Web of Sience KeyUT A1994PP23600008
JaLCDOI 10.18926/AMO/31114
フルテキストURL fulltext.pdf
著者 Nishioka, Keiko| Saito, Chisato| Nagano, Toshiaki| Okano, Mitsuhiro| Nakagawa, Fumio| Nishioka, Satoko| Masuda, Yu| Ono, Toshiro|
抄録 <p>To determine the allergens of mite allergic rhinitis, we studied 31 patients with mite allergic rhinitis by skin tests and nasal provocation tests (15 for skin and 16 for nasal tests) using 6 fractions of Dermatophagoides pteronyssinus (Dp) extract differing in molecular weights (15, 25, 32, 53, 95 and 190 kDMW). In skin testing, patients showed intense positive reactions to the fractions of 15, 25, 32, 95 and 190 kDMW, among which the most patients showed positive reactions to the fractions of 15 and 25 kDMW. Significant differences were found in patients' positive reactivity among each fraction and between low (15 and 25 kD) and high (95 and 190 kD) molecular weight fractions as well. In nasal provocation tests, patients showed intense positive reactions to the fractions of 15, 32, 53 and 95 kDMW, especially to the fractions of 15 and 95 kDMW. Furthermore, the insidence of positive reactions to the 15 kDMW fraction was significantly higher than that to any other fraction in the skin tests (P &#60; 0.05). From these results, the low molecular weight fraction, 15 kDMW, is considered to be the main allergen of this mite and the high molecular weight fractions, 95 and 190 kDMW, may also be considered to be allergens of this mite.</p>
キーワード mite allergen skin test nasal provoration test allergen rhinitis
Amo Type Article
発行日 1994-10
出版物タイトル Acta Medica Okayama
48巻
5号
出版者 Okayama University Medical School
開始ページ 279
終了ページ 282
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 7863799
Web of Sience KeyUT A1994PP23600008
著者 Hanafusa, Tadashi| Shinji, Toshiyuki| Shiraha, Hidenori| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Yumoto, Eichiro| Ono, Toshiro| Koide, Norio|
発行日 2005-01-20
出版物タイトル BMC Cancer
5巻
資料タイプ 学術雑誌論文
著者 永松 知洋| 花元 克巳| 小野 俊朗| 山岡 聖典|
発行日 2005-12
出版物タイトル 環境制御
27巻
資料タイプ 紀要論文
著者 永松 知洋| 花房 直志| 金野 郁雄| 迫田 晃弘| 花元 克巳| 山岡 聖典| 小野 俊朗|
発行日 2008-12
出版物タイトル 環境制御
30巻
資料タイプ 学術雑誌論文
著者 久保田 尚浩| ポジャナピモン チャイワット| 福田 文夫| 藤井 雄一郎| 小野 俊朗| 倉藤 祐輝| 尾頃 敦郎| 功刀 幸博| 小林 和司| 茂原 泉| 山下 裕之| 藤島 宏之|
発行日 2009-02
出版物タイトル 岡山大学農学部学術報告
98巻
1号
資料タイプ 紀要論文
著者 小野 俊朗|
発行日 2002-09-30
出版物タイトル 岡山医学会雑誌
114巻
2号
資料タイプ 学術雑誌論文
著者 小野 俊朗|
発行日 2005-05-30
出版物タイトル 岡山医学会雑誌
115巻
1号
資料タイプ 学術雑誌論文
著者 中川 和彦| 野口 雄司| 奥村 英雄| 佐藤 修一郎| 田中 志幸| 下野 玄英| アリ・エルディブ アリ モハメド| 青江 基| 小野 俊朗| 上中 明子| 大原 信哉| 吉野 正| 山下 和城| 角田 司| 清水 信義| 中山 睿一|
発行日 2007-09-03
出版物タイトル 岡山医学会雑誌
119巻
2号
資料タイプ 学術雑誌論文