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ID 52023
フルテキストURL
著者
Kubota, Junichi Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol
Ikeda, Fusao Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol
Terada, Ryo Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol
Kobashi, Haruhiko Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol
Fujioka, Shin-ichi Okayama Saiseikai Gen Hosp, Dept Internal Med
Okamoto, Ryoichi Hiroshima City Hosp, Dept Internal Med
Baba, Shinsuke Kagawa Prefectural Cent Hosp, Dept Internal Med
Morimoto, Youichi Fukuyama City Hosp, Dept Internal Med
Ando, Masaharu Mitoyo Gen Hosp, Dept Internal Med
Makino, Yasuhiro Natl Hosp Org Iwakuni Clin Ctr, Dept Gastroenterol
Taniguchi, Hideaki Sumitomo Besshi Hosp, Dept Internal Med
Yasunaka, Tetsuya Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol
Miyake, Yasuhiro Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol
Iwasaki, Yoshiaki Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol
Yamamoto, Kazuhide Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol
抄録
Recent routine testing for liver function and anti-mitochondrial antibodies has increased the number of newly diagnosed patients with primary biliary cirrhosis (PBC). This study investigated the prognosis of asymptomatic PBC patients, focusing on age difference, to clarify its effect on the prognosis of PBC patients. The study was a systematic cohort analysis of 308 consecutive patients diagnosed with asymptomatic PBC. We compared prognosis between the elderly (55 years or older at the time of diagnosis) and the young patients (< 55 years). The mortality rate of the patients was also compared with that of an age- and gender-matched general population. The elderly patients showed a higher aspartate aminotransferase-to-platelet ratio, and lower alanine aminotransferase level than the young patients (P < 0.01 and P = 0.03, respectively). The two groups showed similar values for alkaline phosphatase and immunoglobulin M. Death in the young patients was more likely to be due to liver failure (71%), while the elderly were likely to die from other causes before the occurrence of liver failure (88%; P < 0.01), especially from malignancies (35%). The mortality rate of the elderly patients was not different from that of the age- and gender-matched general population (standardized mortality ratio, 1.1; 95% confidence interval, 0.6-1.7), although this rate was significantly higher than that of the young patients (P = 0.044). PBC often presents as more advanced disease in elderly patients than in the young. However, the mortality rate of the elderly patients is not different from that of an age- and gender-matched general population.
キーワード
Primary biliary cirrhosis
Age difference
Mortality rate
発行日
2009-09
出版物タイトル
Journal of Gastroenterology
44巻
9号
開始ページ
1000
終了ページ
1006
ISSN
0944-1174
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.1007/s00535-009-0090-2
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/51954
言語
English
論文のバージョン
author
査読
有り
DOI
Web of Sience KeyUT