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ID 14745
Eprint ID
14745
フルテキストURL
タイトル(別表記)
Studies on chemotherapy for small cell lung cancer Part 2. Patterns of relapse in patients with small cell lung cancer receiving chemotherapy with or without Radiotherapy
著者
山下 英敏 岡山大学医学部第二内科学教室
抄録
Between 1976 and 1987, a total of 180 patients with small cell lung cancer who were entered into three protocol studies of an intensive chemotherapy with or without radiotherapy was fully evaluated for tumor response and survival. Of them, 74 patients achieved a complete response (CR) : 47 out of 91 patients with limited disease (LD) and 27 out of 89 patients with extensive disease (ED). The author analysed the pattern of relapse among the 74 patients in an attempt to clarify the role of chest irradiation and/or prophylactic cranial irradiation. Of 47 patients with LD achieving a CR, 20 patients (43%) developed initial relapse in the chest and seven (15%) developed it in the brain. Of the 27 patients with extensive disease, the chest was also the most frequent site of initial relapse (44%) followed by the brain (19%). In patients with LD receiving chemotherapy plus chest irradiation, the rate of initial relapse in the chest and the cumulative actuarial probability for initial chest relapse 2 years later were 29% and 37%, respectively. These figures were siginificantly lower than the rate of 69% and the probability of 69% for patients receiving chemotherapy alone (p<0.05). The patient survival was improved by the addition of chest irradiation substantially, but not significantly. However, long-term disease-free survivors predominated in the group of patients receiving chemotherapy plus chest irradiation. Prophylactic cranial irradiation exerted no significant advantage for prolonging survival. However, it showed a trend for reducing the brain relapse in complete responders. These findings indicate that chest irradiation concomitant with intensive chemotherapy may be effective for prolonging suvival in patients with LD through preventing relapse from the chest.
キーワード
Pattern of relapse
Small cell lung cancer
chest irradiation
prophylactic cranial irradiation
備考
原著
発行日
1991
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
103巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1311
終了ページ
1321
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/103/11-12/103_11-12_1311/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma