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ID 21138
Eprint ID
21138
フルテキストURL
タイトル(別表記)
The Effect of Thermal Spring Water on Drug Absorption in Special Reference to Aspirin and Indomethacin
著者
岡本 輝子 岡山大学医学部附属病院三朝分院
平尾 光宏 岡山大学医学部附属病院三朝分院
古野 勝志 岡山大学医学部附属病院三朝分院
抄録
It is thought that a drug reacts differently with media taken internally. The solubility of Aspirin is assured 600μg/ml in 30min. with Misasa spring water, whereas 400μg/ml with plain water. The parallel difference of 200μg/ml follows 10 min. thereafter. Maximum serum concentratin of 200μg/ml is obtained 2 hours after the internal use of Aspirin with Misasa spring water in parallel difference of 20μg/ml with plain water. In the case of Indomethacin intake, maximum serum concentration of 1.5μg/ml is obtained in 2 hours with plain water, whereas maximum serum concentration of 1μg/ml is obtained in the same period with Misasa spring water. However, the difference of 0.25μg/ml in serum concentration between the media internally taken is seen initially and after 4 hours under high concentration of Indomethacin. We, therefore, assume tentatively that the effect of Aspirin and Indomethacin is supposed to be enhanced with Misasa spring water taken internally.
備考
原著論文 (Original Papers)
発行日
1982-03-25
出版物タイトル
岡山大学温泉研究所報告
出版物タイトル(別表記)
Papers of the Institute for Thermal Spring Research, Okayama University
52巻
出版者
岡山大学温泉研究所
出版者(別表記)
Institute for Thermal Spring Research, Okayama University
開始ページ
45
終了ページ
50
ISSN
0369-7142
NCID
AN00032853
資料タイプ
紀要論文
言語
Japanese
論文のバージョン
publisher
査読
無し
Eprints Journal Name
mmc