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ID 31995
JaLCDOI
フルテキストURL
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著者
Takeuchi, Mamoru Okayama University
Morita, Kiyoshi Okayama University
Iwasaki, Tatsuo Okayama University
Toda, Yuichiro Okayama University
Oe, Katsunori Okayama University
Taga, Naoyuki Okayama University
Hirakawa, Masahisa Okayama University
抄録

To elucidate the effect of adrenomedullin (AM) on fluid homeostasis under cardiopulmonary bypass (CPB), we investigated the serial changes in plasma AM and other parameters related to fluid homeostasis in 13 children (average age, 28.2 months) with congenital heart disease during cardiac surgery under CPB. Arterial blood and urine samples were collected just after initiation of anesthesia, just before commencement of CPB, 10 min before the end of CPB, 60 min after CPB, and 24 h after operation. Plasma AM levels increased significantly 10 min before the end of CPB and decreased 24 h after operation. Urine volume increased transiently during CPB, which paralleled changes in AM. Simple regression analysis showed that plasma AM level correlated significantly with urinary vasopressin, urine volume, urinary sodium excretion, and plasma osmolarity. Stepwise regression analysis indicated that urine volume was the most significant determinant of plasma AM levels. Percent rise in AM during CPB relative to control period correlated with that of plasma brain natriuretic peptide (r = 0.57, P < 0.01). Our results suggest that AM plays an important role in fluid homeostasis under CPB in cooperation with other hormones involved in fluid homeostasis.

キーワード
adrenomedullin
cardiopulmonary bypass
vasopressin
pediatric cardiac surgery
brain natriuretic peptide
Amo Type
Article
発行日
2001-08
出版物タイトル
Acta Medica Okayama
55巻
4号
出版者
Okayama University Medical School
開始ページ
245
終了ページ
252
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT