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ID 18001
Eprint ID
18001
フルテキストURL
Thumnail 82_447.pdf 1.36 MB
タイトル(別表記)
Failure of lipid peroxidation reaction in ascites hepatoma cells (AH-130) and its mechanism
著者
後藤 信行 岡山大学医学部癌源研究施設生化学部
抄録
Various tissue homogenates can produce lipid peroxide during incubation with Fe(++) or Co(++) in the presence of oxygen. But the homogenate of actively growing cells diminishes or fails to elicit the lipid peroxide formation. In the present report the author studied the mechanism of the failure of lipid peroxidation reaction of ascites hepatoma cells (AH-130) and the following results were obtained. 1. One of the facts of failure of lipid peroxidation reaction was the reduced arachidonic acid content in phospholipid fraction of ascites hepatoma cells. 2. The other facter was the presence of an inhibitor of lipid peroxidation in acetone soluble fraction of the ascites hepatoma cell membrane fractions. Therefore, the phospholipid fraction of the ascites hepatoma cells shows the lipid peroxidation reaction by the treatment with Fe(++). 3. The inhibitor was also found in the acetone soluble fraction of normal rat liver cells but the content was quite low. 4. The chemical nature of the inhibitor was different from the well known, antioxidant such as α-tocopherol, Coenzyme Q and Vitamin K. The chemical structure has not been identified yet, On the basis of these data the author discussed about the mechanism of the regulation of lipid peroxidation reaction in the cells with respect to the regulation of cell growth and cancer cell specificity and to the aging.
発行日
1970-12-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
82巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
447
終了ページ
458
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/82/11-12/82_11-12_447/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma