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ID 32274
JaLCDOI
フルテキストURL
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著者
Hirotsune, Nobuyuki Okayama University
Kinugasa, Kazushi Okayama Rehabilitation Center for Traumatic Apallics
Mandai, Shinya Kagawa Prefectual Central Hospital
Tokunaga, Koji Okayama University
Handa, Akira Okayama University
Kawada, Sanami Okayama University
Ohmoto, Takashi Okayama University
抄録

Cellulose acetate polymer (CAP) solution is a new liquid embolic material, and it has been used clinically for the thrombosis of cerebral aneurysms. The purpose of the study was to test a method of aneurysm treatment. In an experimental model, retrievable interlocking detachable coils (IDCs) were used to create an intraaneurysmal frame or prop and then CAP was injected into 20 experimentally induced canine cervical aneurysms. Intraaneurysmal thrombosis was induced 1 week after aneurysm creation. Complete thrombosis was attempted in 12 aneurysms, and partial thrombosis was attempted in 4. Four other aneurysms served as controls. Follow-up angiography was performed for up to 8 weeks, and with the exception of 4 aneurysms, which were kept for a 2-year long-term follow-up study, the aneurysms were then harvested for histological examination. Thrombosis was successfully achieved in all cases except for 2 enlarged aneurysms that were initially partially thrombosed. No thromboembolism to distal vessels was observed. No compaction or shift of the CAP-IDC complex occurred even after 2 years. Histologically, CAP and IDCs conformed to the massive thrombotic complex without any fragmentation. By creating a frame or prop with retrievable microcoils, we were able to inject the CAP implies a comparison safely and precisely than has been previously reported. Our findings suggest that this method will be useful for the treatment of cerebral aneurysms.

キーワード
experimentally induced aneurysm
cellulose acetate polymer (CAP)
interlocking detachable coil (IDC)
endovascular technique
Amo Type
Article
発行日
2000-08
出版物タイトル
Acta Medica Okayama
54巻
4号
出版者
Okayama University Medical School
開始ページ
153
終了ページ
164
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT