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ID 19005
Eprint ID
19005
フルテキストURL
Thumnail 70_1897.pdf 844 KB
タイトル(別表記)
Studies on the Drug-Resistance of Tubercle-Bacilli Part 1. On the Reversibility of Drug Resistance in Tubercle Bacilli
著者
景山 統二郎 岡山大学医学部平木内科教室
抄録
With a view to elucidate the mechanism of reversibility of resistant tubercle bacilli, the author has performed in vitro experiments of resistance reversibility by observing changes occurring in successive culture of resistant bacilli together with different antituberculous agents, the filtrate of sensitive strain or dead bacilli, by changing ingredients of successive media; and also by injecting different kinds of antituberculous agents into imice the rever sibility in vivo has been studied. As the result the following interesting data were obtained. 1) In the successive cultures of SM-resistant H(37)Rv-strain and INAH-resistant-H(37)Rv-strain in the medium of Kirchner's albumin or serum liquid medium, each loaded with PAS, Viomycin, Pyrazinamide, INAH or SM, no reversibility of resistance could be recognized. 2) In the successive cultures of SM-resistant H(37)Rv-strain and SM-resistant avian type Takeo strain in the medium loaded with the filtrate of sensitive parent strain or dead bacilli, no reversibility of resistance could be observed. 3) In the cases of successive cultures of SM-resistant-H(37)Rv-strain and INAH-resistant-H(37)Rv-strain in modified media of 1% Ogawa's medium, SM-resistant bacilli revealed no resistance-reversibility in any of these media. INAH-resistant strain successively cultured in the medium containing solely KH(2)PO(4) or only sodium glutamate, they began to show a diminution in resistance about the fifth generation. As for the mechanism of this diminution in resistance it is possible to assume an induced backmutation in modified media. 4) In the experiments with mice, the diminution in resistance has been observed in the cases inoculated with SM-resistant strain and injected with INAH as well as in the cases inoculated with INAH resistant strain and injected with SM. It is assumed that the susceptibility of resistant bacilli to other agents is elevated in vivo.
発行日
1958-06-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
70巻
6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1897
終了ページ
1909
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/70/6/70_6_1897/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma