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ID 32953
フルテキストURL
著者
Maki, Yu Okayama University
Murakami, Jun Okayama University
Asaumi, Jun-ichi Okayama University
Tsujigiwa, Hidetsugu Okayama University
Nagatsuka, Hitoshi Okayama University
Kokeguchi, Susumu Okayama University
Fukui, Kazuhiro Okayama University
Kawai, Noriko Okayama University
Yanagi, Yoshinobu Okayama University
Kuroda, Masahiro Okayama University
Tanaka, Noriaki Okayama University
Matsubara, Nagahide Okayama University
Kishi, Kanji Okayama University
抄録

The DNA repair enzyme, O-6-methylguanine-DNA methyltransferase (MGMT) modulates the effectiveness of alkylating agents. However, the relationship between MGMT and the sensitivities to other agents has not been explored. In the present study, the association between MGMT expression and the cellular sensitivity to the platinum agent, CDDP was examined in four human oral cancer cell tines. CDDP depleted MGMT protein and mRNA levels in all four cell tines. Two cell lines with low MGMT expression were sensitive to an alkylating agent, N-methyl-N'-nitro-N-nitrosoguanidine and CDDP, whereas two other cell tines with high MGMT expression were resistant to both agents. Furthermore, the addition of the MGMT inhibitor, O-6-benzylguanine (O-6-BG), invariably enhanced CDDP sensitivity. CDDP depleted MGMT expression, and CDDP sensitivity was enhanced by O-6-BG. These results provide valuable information about the relationship between MGMT expression and CDDP sensitivity in oral cancer chemotherapy. (c) 2005 Elsevier Ltd. All rights reserved.

キーワード
mgmt
cddp
o-6-bg
oral cancer
備考
Digital Object Identifer:10.1016/j.oraloncology.2005.05.011
Published with permission from the copyright holder. This is the institute's copy, as published in Oncology, July 2005, Volume 41, Issue 10, Pages 984-993.
Publisher URL:http://dx.doi.org/10.1016/j.oraloncology.2005.05.011
Direct access to Thomson Web of Science record
Copyright © 2005 Elsevier Ltd All rights reserved. All rights reserved.
発行日
2005-7
出版物タイトル
Oral Oncology
41巻
10号
開始ページ
984
終了ページ
993
資料タイプ
学術雑誌論文
言語
English
査読
有り
DOI
Web of Sience KeyUT
Submission Path
dentistry_general/8