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ID 15904
Eprint ID
15904
フルテキストURL
Thumnail 100_331.pdf 578 KB
タイトル(別表記)
Evaluation of new exocrine pancreatic function tests and their application to clinical research I. Aging and exocrine pancreatic function as evaluated by fecal chymotrypsin activity
著者
松本 秀次 岡山大学医学部附属環境病態研究施設成人病学分野
抄録
To examine the relationship between aging and pancreatic exocrine function, fecal chymotrypsin activity (FCA) was measured by a photometric method in 62 healthy controls (20 to 87 years old, with a mean age of 51.0), 43 patients with non-pancreatic diseases ( 31 to 83 years old, with a mean age of 55.7), 40 controls with no known digestive diseases in an old-age home (63 to 92 years old, with a mean age of 77.6) and 22 patients with chronic pancreatitis (17 to 72 years old, with a mean age of 52.9).Pancreatic exocrine function decreased significantly with aging as indicated by: (a) a significant inverse correlation between aging and FCA in the 62 healthy controls (r=-0.56, p<0.001), in the 43 patients with non-pancreatic diseases (r=-0.58, p<0.001), and in the 40 controls in an old-age home (r=-0.52, p<0.001): and (b) a significantly lower FCA in the 21 healthy controls over 65 years of age (designated as B-group of healthy controls) than the 41 healthy controls under 65 years of age (designated as A-group of healthy controls).The 40 controls in an old-age home showed significantly lower FCA than the B-group of healthy controls. This result was ascribed to the fact that the former group comprised significantly older subjects than the latter.No significant difference was found in FCA between patients with chronic pancreatitis and B-group of healthy controls as well as controls in an old-age home. When the mean -2SD of the A-group of healthy controls was set as the lower limit of normal, 59.1 percent of patients with chronic pancreatitis, 52.4 percent of B-group healthy controls and 62.5 percent of controls in an old-age home showed abnormally low levels of FCA. This result indicates that the FCA value should be carefully interpreted with respect to the age of the patient before making the diagnosis of pancreatic disease.
キーワード
aging
fecal chymotrypsin activity
exocrine pancreatic function
pancreatic enzyme
発行日
1988
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
100巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
331
終了ページ
339
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/100/3-4/100_3-4_331/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma