著者 Okada, Yoshiki| Abe, Nobuhiro| Hisamori, Noriyuki| Kaneeda, Toshiaki| Moriyama, Shigeaki| Ohmori, Hitoshi| Mizutani, Masayoshi| Yanai, Hiroyuki| Nakashima, Yoshio| Yokoyama, Yusuke| Ozaki, Toshifumi|
発行日 2017-02
出版物タイトル Acta Medica Okayama
71巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/54825
JaLCDOI 10.18926/AMO/54505
フルテキストURL 70_4_285.pdf
著者 Tanaka, Takashi| Gobara, Hideo| Inai, Ryota| Iguchi, Toshihiro| Tada, Akihiro| Sato, Shuhei| Yanai, Hiroyuki| Kanazawa, Susumu|
抄録 We present a case of a 66-year-old man with esophageal carcinoma. 18Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for evaluating distant metastasis and staging revealed 18F-FDG uptake in the third lumbar vertebra and other vertebrae. Magnetic resonance imaging could not differentiate bone metastases from benign bone lesions. We considered the possibility of bone marrow reconversion. 111Indium chloride (111In-Cl3) scintigraphy with single-photon emission computed tomography/computed tomography (SPECT/CT) revealed erythroid bone marrow components in the bone lesions. The diagnosis of bone marrow reconversion was pathologically confirmed by a bone biopsy of the third lumbar vertebra. The patient underwent esophagectomy and has remained disease-free in the 2 years since. To the best of our knowledge, this is the first report to describe the usefulness of 111In-Cl3 with SPECT/CT for the diagnosis of bone marrow reconversion.
キーワード 111Indium chloride scintigraphy SPECT/CT bone marrow reconversion 18F-FDG PET/CT bone metastasis
Amo Type Case Report
発行日 2016-08
出版物タイトル Acta Medica Okayama
70巻
4号
出版者 Okayama University Medical School
開始ページ 285
終了ページ 289
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
Submission Path amo/vol70/iss4/9
PubMed ID 27549674
Web of Sience KeyUT 000384748600009
JaLCDOI 10.18926/AMO/54423
フルテキストURL 70_3_223.pdf
著者 Ebara, Shin| Kobayashi, Yasuyuki| Sasaki, Katsumi| Araki, Motoo| Sugimoto, Morito| Wada, Koichirou| Fujio, Kei| Takamoto, Atsushi| Watanabe, Toyohiko| Yanai, Hiroyuki| Nasu, Yasutomo|
抄録 The present case report describes a case of recurrent and advanced urachal carcinoma including neuroendocrine features with iliac bone metastasis after partial cystectomy and adjuvant chemotherapy consisting of irinotecan and cisplatin in a 32-year-old man. He received gemcitabine/cisplatin/ paclitaxel (GCP) combination chemotherapy, consisting of gemcitabin (1,000mg/m2) on day 1, 8, cisplatin (70mg/m2) on day 1, and paclitaxel (80mg/m2) on day 1 and 8. After three cycles of chemotherapy, PET-CT showed complete regression of the disease. So the patient underwent total cystourethrectomy, and histological examination showed an almost complete pathological response. External beam radiation therapy was also given to the ileac bone metastasis regions. However, PET-CT taken 17 months after the external beam radiation showed multiple lung metastases. He received GCP chemotherapy again, which resulted in a complete response again after three cycles of chemotherapy. This is the first report on GCP chemotherapy used not only as a salvage chemotherapy but also as a rechallenge regimen for metastatic urachal cancer including a neuroendocrine component.
Amo Type Case Report
発行日 2016-06
出版物タイトル Acta Medica Okayama
70巻
3号
出版者 Okayama University Medical School
開始ページ 223
終了ページ 227
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
Submission Path amo/vol70/iss3/11
PubMed ID 27339213
Web of Sience KeyUT 000379406100011
JaLCDOI 10.18926/AMO/53341
フルテキストURL 69_2_119.pdf
著者 Terasaka, Tomohiro| Hagiya, Hideharu| Kimura, Kosuke| Nada, Takahiro| Nakamura, Eri| Hanayama, Yoshihisa| Sugiyama, Hitoshi| Kobayashi, Yasuyuki| Yanai, Hiroyuki| Otsuka, Fumio|
抄録 We report the case of a 46-year-old hypertensive Japanese female with renal insufficiency related to unilateral renal hypoplasia. The patient was found to have developed paraganglioma in the retroperitoneal space over a 5-year period. Catecholamine-producing tumors are not usually recognized as conditions associated with renal hypoplasia. Our long-term observation of the patient eventually led us to the diagnosis of paraganglioma. In hypertensive patients with chronic kidney disease, not only the renin-angiotensin-aldosterone system but also catecholamine activity may be involved, particularly in the patients whose cases are complicated with unilateral renal hypoplasia.
キーワード catecholamine paraganglioma renal hypoplasia renovascular hypertension secondary hypertension
Amo Type Case Report
発行日 2015-04
出版物タイトル Acta Medica Okayama
69巻
2号
出版者 Okayama University Medical School
開始ページ 119
終了ページ 122
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン publisher
査読 有り
Submission Path amo/vol69/iss2/7
PubMed ID 25899634
Web of Sience KeyUT 000353181700007
著者 柳井 広之|
発行日 2013-08-01
出版物タイトル 岡山医学会雑誌
125巻
2号
資料タイプ 学術雑誌論文
著者 田辺 俊介| 白川 靖博| 前田 直見| 大原 利章| 野間 和広| 櫻間 教文| 柳井 広之| 山辻 知樹| 猶本 良夫| 藤原 俊義|
発行日 2012-08-01
出版物タイトル 岡山医学会雑誌
124巻
2号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/45273
フルテキストURL 65_2_135.pdf
著者 Matsuo, Toshihiko| Himei, Kengo| Ishii, Keita| Ichimura, Kouichi| Yanai, Hiroyuki| Nose, Soichiro| Mimura, Tetsushige|
抄録 An 18-year-old woman with a 2-year history of hypertension and headache was diagnosed with noradrenalin-secreting bilateral adrenal pheochromocytomas with paragangliomas in the background of von Hippel-Lindau disease with family histories and a missense mutation, 712C to T (Arg167Trp) in the VHL gene. She had optic disc hemangioma in the left eye which gradually enlarged and caused serous retinal detachment on the macula in one year. Low-dose external beam radiation (20 Gy) was administered to the left eye using a lens-sparing single lateral technique. She underwent craniotomy for cerebellar hemangioblastoma at the age of 22 years and total pancreatectomy for multiple neuroendocrine tumors at the age of 24 years. In the 6-year follow-up period after the radiotherapy, the optic disc hemangioma gradually reduced in size and its activity remained low, allowing good central vision to be maintained. External beam radiation is recommended as a treatment option for the initial therapy for optic disc hemangioma.
キーワード retinal (papillary, optic disc) hemangioma von Hippel-Lindau disease pheochromocytoma pancreatic neuroendocrine tumor external beam radiation (radiotherapy)
Amo Type Case Report
発行日 2011-04
出版物タイトル Acta Medica Okayama
65巻
2号
出版者 Okayama University Medical School
開始ページ 135
終了ページ 141
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン publisher
査読 有り
Submission Path amo/vol65/iss2/10
PubMed ID 21519372
Web of Sience KeyUT 000289818800010
JaLCDOI 10.18926/AMO/31848
フルテキストURL fulltext.pdf
著者 Iishi, Tatsuhiko| Hiraki, Takao| Mimura, Hidefumi| Gobara, Hideo| Kurose, Taichi| Fujiwara, Hiroyasu| Sakurai, Jun| Yanai, Hiroyuki| Yoshino, Tadashi| Kanazawa, Susumu|
抄録 <p>The present study was performed to clarify the effect of hypertonic saline infusion into the lung parenchyma on radiofrequency ablation (RFA) of the lungs. A total of 20 ablation zones were created in 3 pigs. The ablation zones were divided into 3 groups. Group 1 (n6) consisted of ablation zones created by applying smaller radiofrequency (RF) power without saline infusion;group 2 (n5) zones were created by applying greater RF power without saline infusion;and group 3 (n9) zones were created by applying greater RF power with saline infusion. The techniques of saline infusion included administration of hypertonic saline 1ml before RFA, followed by continuous administration at a rate of 1ml/min during the first 2min after the initiation of RFA. The ablation parameters and coagulation necrosis volumes were compared among the groups. Group 3 had a tendency toward smaller mean impedance than group 1 (p0.059) and group 2 (p0.053). Group 3 showed significantly longer RF application time than group 2 (p0.004) and significantly greater maximum RF power than group 1 (p0.001) and group 2 (p0.004). Group 3 showed significantly larger coagulation necrosis volume (mean, 1,421mm3) than group 2 (mean, 858mm3, p0.039) and had a tendency toward larger necrosis volume than group 1 (mean, 878mm3, p0.077). Although this small study had limited statistical power, hypertonic saline infusion during RFA appeared to enlarge coagulation necrosis of the lung parenchyma.</p>
キーワード radiofrequency ablation lung experimental study
Amo Type Original Article
発行日 2009-06
出版物タイトル Acta Medica Okayama
63巻
3号
出版者 Okayama University Medical School
開始ページ 137
終了ページ 144
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol63/iss3/3
PubMed ID 19571900
Web of Sience KeyUT 000267388200003
JaLCDOI 10.18926/AMO/31108
フルテキストURL fulltext.pdf
著者 Miyatani, Katsuya| Takahashi, Kiyoshi| Yanai, Hiroyuki| Yoshino, Tadashi| Akagi, Tadaatsu|
抄録 <p>Previously, we reported that interleukin-2 (IL-2)-stimulated helper T cells produced an unknown soluble factor which induced dendritic cell-like differentiation in primary cultures of monocytic leukemia cells and we referred to this factor as dendritic cell differentiation factor (DCDF). In this study, we attempted to purify and characterize DCDF and investigated its biological effect on normal human monocytes. Gel filtration chromatography indicated that the molecular weight of DCDF is approximately 30-35 kDa. Chromatofocusing indicated that the isoelectric point of DCDF is approximately 5.0. DCDF, partially purified by subsequent gel filtration, chromatofocusing, and hydrophobic chromatography, significantly enhanced the HLA-DR expression of normal human monocytes and a human monocytic leukemia cell line, THP-1. This biological activity was not neutralized by any known antibodies to human cytokines. DCDF significantly amplified the T-cell stimulatory activity of monocytes in the allogeneic mixed leukocyte reaction (MLR). Moreover, DCDF significantly enhanced IL-1 beta and IL-6 production by monocytes in a dose-dependent manner. These results suggest that DCDF is a novel human cytokine which stimulates the accessory cell function of monocytes.</p>
キーワード dendritic cell differentiation protein purification cytokine
Amo Type Article
発行日 1994-04
出版物タイトル Acta Medica Okayama
48巻
2号
出版者 Okayama University Medical School
開始ページ 67
終了ページ 72
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol48/iss2/1
PubMed ID 8042536
Web of Sience KeyUT A1994NJ77500001
JaLCDOI 10.18926/AMO/30764
フルテキストURL fulltext.pdf
著者 Ino, Hideo| Hayashi, Kazuhiko| Yanai, Hiroyuki| Teramoto, Norihiro| Koirala, Tirtha Raj| Chen, Hong-Li| Oka, Takashi| Yoshino, Tadashi| Takahashi, Kiyoshi| Akagi, Tadaastu|
抄録 <p>A simian cell line, Si-IIA, harboring Epstein-Barr-virus (EBV) -related herpesvirus (Si-IIA-EBV), produces malignant lymphoma in rabbits when administered by intravenous inoculation. In this study, we analyzed the Si-IIA-EBV genome and compared it with human EBV and herpesvirus macaca fascicularis 1 (HVMF 1 ), which is associated with B-cell lymphoma developing in SIV-infected immunosuppressed monkeys. DNA from Si-IIA-EBV was amplified by the polymerase chain reaction using three different primer pairs complementary to human EBV (B95-8) DNA; two of the primer pairs covered part of the long internal repeat 1 region (IR 1) and the third covered part of the BRRF 1 region. Direct sequencing of the three PCR products revealed that Si-IIA-EBV DNA had about 82% nucleotide homology to the human EBV DNA in all three regions and 92.4% homology to HVMF1 in the IR1 region. The blotting pattern by Southern blot analysis was different between Si-IIA-EBV and human EBV.</p>
キーワード Epstein-Barr virus HVMF 1 lymphoma ?monkey cell line PCR
Amo Type Article
発行日 1997-08
出版物タイトル Acta Medica Okayama
51巻
4号
出版者 Okayama University Medical School
開始ページ 207
終了ページ 212
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol51/iss4/4
PubMed ID 9284968
Web of Sience KeyUT A1997XU03200004
JaLCDOI 10.18926/AMO/30509
フルテキストURL fulltext.pdf
著者 Yanai, Hiroyuki| Yoshino, Tadashi| Takahashi, Kiyoshi| Ninomiya, Yoshifumi| Akagi, Tadaatsu|
抄録 <p>Circulating hepatitis C virus (HCV) particles can be fractionated by means of differential flotation centrifugation. It is reported that in the bottom fraction HCV is in the form immune complexes, whereas in the top, it is free of antibodies. We evaluated the significance of circulating complex and free HCV in chronic hepatitis C, and assessed the relationship in terms of the response to interferon (IFN) therapy. We examined sera before, just after, and 1 year after administering IFN to 18 patients with chronic hepatitis C, 10 of whom responded (group CR), and 8 did not (group NR). The amounts of virus were similar between both groups before therapy. After differential flotation centrifugation with 1.063 g/ml of NaCl, the top and bottom fractions were assayed for HCV RNA. Before therapy, HCV RNA was detected in the top fraction in 1 of 10 in group CR, and in 6 of 8 in group NR (P &#60; 0.05, chi-square test). HCV RNA was positive in the bottom fraction of all samples. In a follow-up study of group NR, HCV RNA was detected in the top fraction in 3 of 8 just after IFN therapy, and in 7 of 8 after 1 year. This study suggests that the presence of HCV in the top fraction can predict a poor response to IFN therapy.</p>
キーワード IL-2R ??chain phorbol ester monocyte differentiation protein kinase
Amo Type Article
発行日 1996-06
出版物タイトル Acta Medica Okayama
50巻
3号
出版者 Okayama University Medical School
開始ページ 145
終了ページ 150
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol50/iss3/5
PubMed ID 8805853
Web of Sience KeyUT A1996UU60400005
著者 箭内 博行|
発行日 1983-02-28
出版物タイトル 岡山医学会雑誌
95巻
1-2号
資料タイプ 学術雑誌論文
著者 松岡 順治| 田渕 陽子| 小野 亮子| 今田 孝子| 梅岡 達生| 渡辺 直樹| 元木 崇之| 松川 啓義| 猶本 良夫| 田中 紀章| 柳井 広之| 大森 昌子|
発行日 2006-09-01
出版物タイトル 岡山医学会雑誌
118巻
2号
資料タイプ 学術雑誌論文
著者 松岡 順治| 田渕 陽子| 伊藤 充矢| 小野 亮子| 今田 孝子| 元木 崇之| 松川 啓義| 大森 昌子| 柳井 広之| 猶本 良夫| 田中 紀章|
発行日 2006-09-01
出版物タイトル 岡山医学会雑誌
118巻
2号
資料タイプ 学術雑誌論文
著者 柳井 広之|
発行日 1996-03-31
出版物タイトル
資料タイプ 学位論文