このエントリーをはてなブックマークに追加
ID 30509
JaLCDOI
フルテキストURL
著者
Yanai, Hiroyuki Okayama University
Yoshino, Tadashi Okayama University
Takahashi, Kiyoshi Okayama University
Ninomiya, Yoshifumi Okayama University
Akagi, Tadaatsu Okayama University
抄録

Circulating hepatitis C virus (HCV) particles can be fractionated by means of differential flotation centrifugation. It is reported that in the bottom fraction HCV is in the form immune complexes, whereas in the top, it is free of antibodies. We evaluated the significance of circulating complex and free HCV in chronic hepatitis C, and assessed the relationship in terms of the response to interferon (IFN) therapy. We examined sera before, just after, and 1 year after administering IFN to 18 patients with chronic hepatitis C, 10 of whom responded (group CR), and 8 did not (group NR). The amounts of virus were similar between both groups before therapy. After differential flotation centrifugation with 1.063 g/ml of NaCl, the top and bottom fractions were assayed for HCV RNA. Before therapy, HCV RNA was detected in the top fraction in 1 of 10 in group CR, and in 6 of 8 in group NR (P < 0.05, chi-square test). HCV RNA was positive in the bottom fraction of all samples. In a follow-up study of group NR, HCV RNA was detected in the top fraction in 3 of 8 just after IFN therapy, and in 7 of 8 after 1 year. This study suggests that the presence of HCV in the top fraction can predict a poor response to IFN therapy.

キーワード
IL-2R ??chain
phorbol ester
monocyte
differentiation
protein kinase
Amo Type
Article
発行日
1996-06
出版物タイトル
Acta Medica Okayama
50巻
3号
出版者
Okayama University Medical School
開始ページ
145
終了ページ
150
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT