タイトル(別表記) Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophages
フルテキストURL 126_1.pdf
著者 宮本 聡| 四方 賢一| 宮坂 京子| 岡田 震一| 佐々木 基史| 小寺 亮| 廣田 大昌| 梶谷 展生| 高塚 哲全| 片岡 仁美| 西下 伸吾| 堀口 千景| 船越 顕博| 西森 久和| 内田 治仁| 小川 大輔| 槇野 博史|
キーワード cholecystokinin 糖尿病性腎症 抗炎症作用 腎保護効果
備考 平成24年度岡山医学会賞総合研究奨励賞(結城賞)受賞論文 (The 2012 Okayama Medical Association Award)
出版物タイトル 岡山医学会雑誌
発行日 2014-04-01
126巻
1号
出版者 岡山医学会
出版者(別表記) Okayama Medical Association
開始ページ 1
終了ページ 6
ISSN 0030-1558
NCID AN00032489
資料タイプ 学術雑誌論文
関連URL http://www.okayama-u.ac.jp/user/oma/
言語 Japanese
著作権者 Copyright (c) 2014 岡山医学会
論文のバージョン publisher
査読 有り
DOI 10.4044/joma.126.1
Sort Key 1
Eprints Journal Name joma
参考文献 1) Sugimoto H, Shikata K, Hirata K, Akiyama K, Matsuda M, Kushiro M, Shikata Y, Miyatake N, Miyasaka M, Makino H : Increased expression of intercellular adhesion molecule-1 (ICAM-1) in diabetic rat glomeruli : glomerular hyperfiltration is a potential mechanism of ICAM-1 upregulation. Diabetes (1997) 46, 2075-2081. 2) Okada S, Shikata K, Matsuda M, Ogawa D, Usui H, Kido Y, Nagase R, Wada J, Shikata Y, Makino H : Intercellular adhesion molecule-1-deficient mice are resistant against renal injury after induction of diabetes. Diabetes (2003) 52, 2586-2593. 3) Miyamoto S, Shikata K, Miyasaka K, Okada S, Sasaki M, Kodera R, Hirota D, Kajitani N, Takatsuka T, Kataoka HU, Nishishita S, Sato C, et al. : Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophage : anti-inflammatory effect of cholecystokinin. Diabetes (2012) 61, 897-907. 4) Rehfeld JF : Clinical endocrinology and metabolism. Cholecystokinin. Best Pract Res Clin Endocrinol Metab (2004) 18, 569-586. 5) Crawley JN, Corwin RL : Biological actions of cholecystokinin. Peptides (1994) 15, 731-755. 6) Meng AH, Ling YL, Zhang XP, Zhang JL : Anti-inflammatory effect of cholecystokinin and its signal transduction mechanism in endotoxic shock rat. World J Gastroenterol (2002) 8, 712-717. 7) Li S, Ni Z, Cong B, Gao W, Xu S, Wang C, Yao Y, Ma C, Ling Y : CCK-8 inhibits LPS-induced IL-1beta production in pulmonary interstitial macrophages by modulating PKA, p38, and NF-kappaB pathway. Shock (2007) 27, 678-686. 8) Lacourse KA, Lay JM, Swanberg LJ, Jenkins C, Samuelson LC : Molecular structure of the mouse CCK-A receptor gene. Biochem Biophys Res Commun (1997) 236, 630-635. 9) de Weerth A, Jonas L, Schade R, Schoneberg T, Wolf G, Pace A, Kirchhoff F, Schulz M, Heinig T, Greten H, von Schrenck T : Gastrin/cholecystokinin type B receptors in the kidney : molecular, pharmacological, functional characterization, and localization. Eur J Clin Invest (1998) 28, 592-601. 10) Xu SJ, Gao WJ, Cong B, Yao YX, Gu ZY : Effect of lipopolysaccharide on expression and characterization of cholecystokinin receptors in rat pulmonary interstitial macrophages. Acta Pharmacol Sin (2004) 25, 1347-1353. 11) Sanchez AP, Sharma K : Transcription factors in the pathogenesis of diabetic nephropathy. Expert Rev Mol Med (2009) 11, e13. 12) Takano Y, Yamauchi K, Hayakawa K, Hiramatsu N, Kasai A, Okamura M, Yokouchi M, Shitamura A, Yao J, Kitamura M : Transcriptional suppression of nephrin in podocytes by macrophages : roles of inflammatory cytokines and involvement of the PI3K/Akt pathway. FEBS Lett (2007) 581, 421-426. 13) Leon-Tamariz F, Verbaeys I, Van Boven M, De Cuyper M, Buyse J, de Witte P, Verbruggen A, Cokelaere M : Biodistribution and pharmacokinetics of PEG-10kDa-cholecystokinin-10 in rats after different routes of administration. Curr Drug Deliv (2010) 7, 137-143.
著者 梶谷 展生|
発行日 2011-03-25
出版物タイトル
資料タイプ 学位論文