このエントリーをはてなブックマークに追加
ID 16341
Eprint ID
16341
フルテキストURL
Thumnail 98_809.pdf 1.74 MB
タイトル(別表記)
Toxicity of chlorinated cyclic hydrocarbons I. The effect of administration of chlordane on rat liver and serum, and the levels of certain chemicals in the serum of chlordane workers
著者
森 孝昭 岡山大学医学部公衆衛生教室
抄録
Rats were administered chlordane emulsion orally, and changes in the liver function were studied. The levels of certain chemicals in the serum of chlordane wokers also were determined. The increase in the body weight of rats administered chlordane was suppressed compared to control rats. Liver weights of rats administered chlordane were significantly (p<0.01) greater than those of control rats. Levels of moisture, total lipid, triglycerides and phospholipid per gram liver of rats administered chlordane were significantly (p<0.05) higher than those of control rats. Levels of lipid peroxide of rats administered chlordane were significantly (p<0.05) higher than those of control rats, and increased according to increases in the amount of chlordane administered. Levers of DNP-stimulated ATPase activity in the liver mitochondria of rats administered chlordane were lower than those of control rats. State 4 respiration in the mitochondria of rats administered chlordane was greater than those of control rats. State 3 respiration was the same in both groups. As a result, the respiratory control index (RCI) of administered rats was lower than those of control rats. Levels of triglycerides, total cholesterol and γ-GTP activity in the serum of rats administered chlordane were significantly (p<0.05) higher than those of control rats. Levels of blood suger of rats administered chlordane were significantly (p<0.05) lower than those of control rats. Levels of total cholesterol, triglycerides, activity of CPK and LDH of several tested chlordane wokers were higher than the upper limit of normal persons.
キーワード
テクニカルクロルデン
過酸化脂質
中性脂肪
酸化的リン酸化反応
CPK活性
発行日
1986-10-31
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
98巻
9-10号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
809
終了ページ
818
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/98/9-10/98_9-10_809/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma