岡山医学会 Acta Medica Okayama 0030-1558 71 6-2 1959 耐性と過敏性に及ぼす靜脈麻酔剤並びに寒冷麻酔の影響に関する研究 第2編 海猽のルゴール液に対する耐性並びに過敏性に及ぼすラボナール静脈麻酔および寒冷麻酔の影響 3231 3239 EN Yoshinori Mori The Lugol solution was administrated and the changing of leukocytes, shock symptoms and skin reaction were studied every day after the prelimiary management. Thus the influence of Ravonal intravenous injection and cold anesthesia was researched. The results were as follows: 1) Injecting 0.03cc Lugol solution to normal guinea pigs each weighting 100g, shock symptoms appeared but using 0.01cc solution no general symptoms were found. 2) In normal guinea pigs, leukocytes decrease after the Lugol solution injection. Those which were managed preliminary by Lugol solution, leukocytes incresed in three or five days by the reinjection of Lugol solution. Even by injection of 0.03cc per 100g weight guinea pigs, they showed no shock symptoms and acquired tolerance. 3) On the 10th and 17th day from the preliminary management leukocytes decrease markedly if the reinjection of Lugol solution be done. Shock symptoms will be caused even by injection of 0.01cc per 100g weight guinea pigs and anaphylaxis found. 4) The skin reaction descends on the 3rd and the 5th day from the preliminary management (tolerance). On the 8th day it becomes nearly similar to normal guinea pigs and then gradually moves to anaphylaxis on the 11th and the 17th days. 5) For each reaction above mentioned the intravenous injection of Ravonal and cold anesthesia shows reduction. Only the control effects of Ravonal to the skin reaction is very slight. 6) The controlling mechanism of Ravonal and cold anesthesia for the general anaphylaxis is not the effect of the antigen and antibody combination nor that of the produced chemical reactive substances but is regarded to act on the decrease of reactive power of a living body. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 71 6-2 1959 耐性と過敏性に及ぼす靜脈麻酔剤並びに寒冷麻酔の影響に関する研究 第1編 家兎の卵白アルブミンに対する耐性並びに過敏性に及ぼすラボナール静脈麻酔および寒冷麻酔の影響 3217 3229 EN Yoshinori Mori The general anaphylaxis is obviously influenced by general narcotics and some agents. To make clear of its mechanism this study was done. The ovialbumin was administrated and the change of leukocytes, shock symptoms and skin reaction were studied every day after the preliminary management. Thus the influence of Ravonal intravenous injection and cold anesthesia was researched. The results were as follows; 1) After the injection of ovialbumin, normal rabbits showed decrease of leukocytes. Ravonal and cold anesthesia restrained its decrease. 2) By Ravonal or cold anestheisa alone, the numbers of leukocytes do not show any change. 3) The rabbits injected by ovialbumin 3 times every other day obtained tolerance in 3 or 5 days (decline of reaction) and gradually moved into anaphylaxis (increase of reaction) in 10 to 17 days. 4) In every stadium Ravonal and cold anesthesia restrained the reaction grade. Cold anesthesia restraines the shock symptom and skin reaction much stronger. The reason is considered to owe to anesthetic effect of Ravonal upon the respiratory system which is a shock reactive organ, and the duartion of anesthesia. 5) A reciprocity shows that stronger the anaphylactic shock is the more the leukocytes decrease. 6) These anesthesia restrain not only the general anaphylactic crisis but reduse the reactions in normal rabbits or rabbits with tolerance. They also effect upon the combination of antigen and antibody which is a characteristic in the anaphylactic stadium and show a controling effect. No potential conflict of interest relevant to this article was reported.