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ID 16873
Eprint ID
16873
フルテキストURL
Thumnail 91_567.pdf 443 KB
タイトル(別表記)
Effect of B.C.G. and Splenectomy on survival prolongation of mice with Ehrlich ascites cancer
著者
橋本 雅明 岡山大学医学部第一外科学教室
抄録
In this report, an effective way of B.C.G. in combination with splenectomy is presented for cancer therapy. Ehrlich ascites cancer was inoculated into the footpads of DDS mice. At the appropriate times of tumor growth, a femur was amputated to remove the primary tumor. After several days, the host was rechallenged with Ehrlich ascites cancer. The challange was considered as metastasis. For the first experiments, mice were injected with B.C.G. into primary inoculated tumor and also splenectomized at the amputation. The combined therapy of B.C.G. injection and splenectomy prolonged survival, whereas neither B.C.G. injection nor splenectomy alone did not. For the next examination, the influence of B.C.G. presensitization with or without splenectomy on survival was examined. It was confirmed that the combined therapy was useful for the prolongation of survival. Furthermore, when Ehrlich ascites cancer was reinoculated with sera obtained from tumor bearing mice, splenectomy effectively prolonged survival. The data suggest that B.C.G. therapy is effective for host survival, especially when splenectomy is also performed.
キーワード
BCG
摘脾
エールリッヒ癌
DDSマウス
発行日
1979-06-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
91巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
567
終了ページ
575
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/91/5-6/91_5-6_567/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma