著者 武田 吉正|
発行日 1991
出版物タイトル 岡山医学会雑誌
103巻
4号
資料タイプ 学術雑誌論文
著者 武田 吉正|
発行日 1991-03-28
出版物タイトル
資料タイプ 学位論文
JaLCDOI 10.18926/AMO/32101
フルテキストURL fulltext.pdf
著者 Zhang, Shan| Takeda, Yoshimasa| Hagioka, Shingo| Goto, Keiji| Morita, Kiyoshi|
抄録 <p>To elucidate the mechanism by which hyperbaric oxygen (HBO2) induces electrical discharge, changes in the extracellular concentrations of GABA and glutamate were measured every 5 min using a microdialysis technique in rats during a period of exposure to HBO2 (5 atm abs). Electrical discharge was observed at 28 +/- 4 min after the onset of exposure. Though the extracellular concentrations of glutamate remained unchanged, the extracellular GABA concentrations (pre-exposure level, 0.026 +/- 0.005 microM in dialysate) began to decrease 15 min after the onset of exposure and reached their lowest level (74 +/- 14%, 0.019 +/- 0.004 microM) at the time of appearance of the discharge. There was a close logistic relationship between extracellular GABA concentrations and the discharge incidence, and the extracellular concentrations of GABA causing electrical discharge in 50% of the animals were estimated to be 80% of the pre-exposure level. These results suggest a possible mechanism that HBO2 exposure-induced discharge is caused by the decrease in extracellular concentration of GABA.</p>
キーワード glutamic acid hyperbaric oxygenation gamma-aminobutyricacid microdialysis seizures
Amo Type Article
発行日 2004-04
出版物タイトル Acta Medica Okayama
58巻
2号
出版者 Okayama University Medical School
開始ページ 91
終了ページ 95
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 15255510
Web of Sience KeyUT 000221043700005
JaLCDOI 10.18926/AMO/46627
フルテキストURL 65_3_163.pdf
著者 Arai, Minako| Takata, Ken| Takeda, Yoshimasa| Mizobuchi, Satoshi| Morita, Kiyoshi|
抄録 The mechanism of oxygen toxicity for central nervous system and hyperbaric oxygen (HBO) seizure has not been clarified. Noradrenergic cells in the brain may contribute to HBO seizure. In this study, we defined the activation of noradrenergic cells during HBO exposure by c-fos immunohistochemistry. Electroencephalogram electrodes were pre-implanted in all animals under general anesthesia. In HBO seizure animals, HBO was induced with 5 atm of 100% oxygen until manifestation of general tonic convulsion. HBO non-seizure animals were exposed to 25 min of HBO. Control animals were put in the chamber for 120 min without pressurization. All animals were processed for c-fos immunohistochemical staining. All animals in the HBO seizure group showed electrical discharge on EEG. In the immunohistochemistry, c-fos was increased in the A1, A2 and A6 cells of the HBO seizure group, and in the A2 and A6 cells of the HBO non-seizure group, yet was extremely low in all three cell types in the control group. These results suggest the participation of noradrenaline in HBO seizure, which can be explained by the early excitement of A1 cells due to their higher sensitivity to high blood pressure, hyperoxia, or by the post-seizure activation of all noradrenergic cells.
キーワード hyperbaric oxygen seizure noradrenergic cells immunohistochemistry
Amo Type Original Article
発行日 2011-06
出版物タイトル Acta Medica Okayama
65巻
3号
出版者 Okayama University Medical School
開始ページ 163
終了ページ 168
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 21709713
Web of Sience KeyUT 000292017500002
JaLCDOI 10.18926/AMO/49666
フルテキストURL 67_2_87.pdf
著者 Matsuo, Toshihiko| Takeda, Yoshimasa| Ohtsuka, Aiji|
抄録 The purpose of this study was to develop a series of stereoscopic anatomical images of the eye and orbit for use in the curricula of medical schools and residency programs in ophthalmology and other specialties. Layer-by-layer dissection of the eyelid, eyeball, and orbit of a cadaver was performed by an ophthalmologist. A stereoscopic camera system was used to capture a series of anatomical views that were scanned in a panoramic three-dimensional manner around the center of the lid fissure. The images could be rotated 360 degrees in the frontal plane and the angle of views could be tilted up to 90 degrees along the anteroposterior axis perpendicular to the frontal plane around the 360 degrees. The skin, orbicularis oculi muscle, and upper and lower tarsus were sequentially observed. The upper and lower eyelids were removed to expose the bulbar conjunctiva and to insert three 25-gauge trocars for vitrectomy at the location of the pars plana. The cornea was cut at the limbus, and the lens with mature cataract was dislocated. The sclera was cut to observe the trocars from inside the eyeball. The sclera was further cut to visualize the superior oblique muscle with the trochlea and the inferior oblique muscle. The eyeball was dissected completely to observe the optic nerve and the ophthalmic artery. The thin bones of the medial and inferior orbital wall were cracked with a forceps to expose the ethmoid and maxillary sinus, respectively. In conclusion, the serial dissection images visualized aspects of the local anatomy specific to various procedures, including the levator muscle and tarsus for blepharoptosis surgery, 25-gauge trocars as viewed from inside the eye globe for vitrectomy, the oblique muscles for strabismus surgery, and the thin medial and inferior orbital bony walls for orbital bone fractures.
キーワード stereoscopic camera-captured images education local anatomical dissection orbit eye
Amo Type Original Article
発行日 2013-04
出版物タイトル Acta Medica Okayama
67巻
2号
出版者 Okayama University Medical School
開始ページ 87
終了ページ 91
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23603924
Web of Sience KeyUT 000317801700002
著者 Naito, H.| Takeda, Y.| Danura, T.| Kass, I. S.| Morita, K.|
発行日 2013-04-03
出版物タイトル Neuroscience
235巻
資料タイプ 学術雑誌論文
著者 Danura, Tetsuya| Takeda, Yoshimasa| Shiraishi, Kensuke| Naito, Hiromichi| Mizoue, Ryoichi| Sato, Sachiko| Morita, Kiyoshi|
発行日 2013-07
出版物タイトル Journal of Neurosurgical Anesthesiology
25巻
3号
資料タイプ 学術雑誌論文
著者 武田 吉正|
発行日 2014-10
出版物タイトル Okayama University Medical Research Updates
2巻
資料タイプ その他
著者 Takeda, Yoshimasa| Kawashima, Takahisa| Kiyota, Kazuya| Oda, Shigeto| Morimoto, Naoki| Kobata, Hitoshi| Isobe, Hisashi| Honda, Mitsuru| Fujimi, Satoshi| Onda, Jun| I, Seishi| Sakamoto, Tetsuya| Ishikawa, Masami| Nakano, Hiroshi| Sadamitsu, Daikai| Kishikawa, Masanobu| Kinoshita, Kosaku| Yokoyama, Tomoharu| Harada, Masahiro| Kitaura, Michio| Ichihara, Kiyoshi| Hashimoto, Hiroshi| Tsuji, Hidekazu| Yorifuji, Takashi| Nagano, Osamu| Katayama, Hiroshi| Ujike, Yoshihito| Morita, Kiyoshi|
発行日 2014-12
出版物タイトル Resuscitation
85巻
12号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/54808
フルテキストURL 70_6_455.pdf
著者 Tanino, Masaaki| Kobayashi, Motomu| Sasaki, Toshihiro| Takata, Ken| Takeda, Yoshimasa| Mizobuchi, Satoshi| Morita, Kiyoshi| Nagai, Taku| Morimatsu, Hiroshi|
抄録 Postoperative cognitive dysfunction (POCD) occurs in nearly one-third of patients after non-cardiac surgery. Many animal behavior studies have investigated the effect of general anesthesia on cognitive function. However, there have been no studies examining the effects on working memory specifically, with a focus on the retention of working memory. We demonstrate here that isoflurane anesthesia induces deficits in the retention of spatial working memory in rats, as revealed by an increase in isoflurane-induced across-phase errors in the delayed spatial win-shift (SWSh) task with a 30-min delay in an 8-arm radial arm maze on post-anesthesia days (PADs) 1,2,4, and 10. A post-hoc analysis revealed a significant increase in across-phase errors on PAD 1 and recovery on PAD 10 in the isoflurane group. In contrast, within-phase errors independent of the retention of working memory were unaffected by isoflurane. These results demonstrate that isoflurane anesthesia transiently impairs the retention of spatial working memory in rats.
キーワード postoperative cognitive dysfunction isoflurane spatial working memory retention delayed spatial win-shift task
Amo Type Original Article
発行日 2016-12
出版物タイトル Acta Medica Okayama
70巻
6号
出版者 Okayama University Medical School
開始ページ 455
終了ページ 460
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 28003670