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ID 48708
フルテキストURL
著者
Yamaoka, Kiyonori Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School
Kataoka, Takahiro Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School
Nomura, Takaharu Low Dose Radiation Research Center, Central Research Institute of Electric Power Industry
Taguchi, Takehito Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School
Wang, Da-Hong Public Health, Okayama University Medical School
Mori, Shuji Pharmacology, Okayama University Medical School
Hanamoto, Katsumi Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School
Kira, Shohei Public Health, Okayama University Medical School
抄録
The catalase activities in blood and organs of the acatalasemic (C3H/AnLCsbCsb) mouse of C3H strain are lower than those of the normal (C3H/AnLCsaCsa) mouse. We examined the effects of prior low-dose (0.5 Gy) X-ray irradiation, which reduced the oxidative damage under carbon tetrachloride-induced hepatopathy in the acatalasemic or normal mice. The acatalasemic mice showed a significantly lower catalase activity and a significantly higher glutathione peroxidase activity compared with those in the normal mice. Moreover, low-dose irradiation increased the catalase activity in the acatalasemic mouse liver to a level similar to that of the normal mouse liver. Pathological examinations and analyses of blood glutamic oxaloacetic and glutamic pyruvic transaminase activity and lipid peroxide levels showed that carbon tetrachloride induced hepatopathy was inhibited by low-dose irradiation. These findings may indicate that the free radical reaction induced by the lack of catalase and the administration of carbon tetrachloride is more properly neutralized by high glutathione peroxidase activity and low-dose irradiation in the acatalasemic mouse liver.
キーワード
Acatalasemic mouse
Catalase
CCl<sub>4</sub>
Hepatotoxicity
Low-dose X-irradiation
Antioxidant substances
発行日
2004-05-07
出版物タイトル
Journal of Radiation Research
45巻
1号
出版者
Journal of Radiation Research Editorial Committee
開始ページ
89
終了ページ
95
ISSN
0449-3060
NCID
AA00705792
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/jrr/45/1/45_1_89/_article
言語
English
著作権者
Copyright © 2004 by Journal of Radiation Research Editorial Committee
論文のバージョン
publisher
査読
有り
DOI
PubMed ID
Web of Sience KeyUT